Effects of scratching and other counterstimuli on responses of trigeminothalamic tract neurons to itch-inducing stimuli in rats
| Autor: | Glenn J. Giesler, Brett Lipshetz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Serotonin Hot Temperature Physiology Sensory Processing Rats sprague dawley Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Internal medicine Physical Stimulation Neural Pathways Noxious stimulus Medicine Animals skin and connective tissue diseases Communication Ventral Thalamic Nuclei integumentary system business.industry General Neuroscience musculoskeletal neural and ocular physiology Pruritus Ventral Thalamic Nucleus Scratching eye diseases Trigeminothalamic tract Rats Cold Temperature 030104 developmental biology Endocrinology Cheek nervous system Touch Trigeminal Nucleus Spinal business 030217 neurology & neurosurgery |
| Popis: | Counterstimuli such as scratching, pinching, noxious heat and cold, and innocuous cooling and warming have been shown to inhibit itch in humans. In the present study, the effects of each of these counterstimuli were determined on baseline firing rates and on sustained pruriceptive responses of rat trigeminothalamic tract neurons. We found that scratching had little, if any, effect on baseline firing levels but greatly reduced mean pruriceptive firing following scratching for nearly 1 min. None of the other noxious or innocuous counterstimuli significantly inhibited pruriceptive responses. Our results indicate that scratching, but not other counterstimuli, significantly reduces itch-induced responses of trigeminothalamic tract neurons. |
| Databáze: | OpenAIRE |
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