Occluded Superior Mesenteric Artery and Vein. Therapy with the Stable Gastric Pentadecapeptide BPC 157
| Autor: | Miro Staroveski, Mario Knezevic, Zoran Rajković, Slaven Gojkovic, Domagoj Drmic, Sven Seiwerth, Andrej Šitum, Suncana Sikiric, Hrvoje Vranes, Anita Škrtić, Helena Zizek, Antonio Kokot, Sanja Strbe, Ante Tvrdeić, Antonija Djuzel, Tamara Knezevic, Dominik Malekinusic, Predrag Sikiric, Alenka Boban Blagaic, Eva Lovric, Borna Vrdoljak, Marija Sola, Toni Kolak, Leonardo Patrlj, Ivan Krezic, Marija Milavić |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
QH301-705.5 Medicine (miscellaneous) 01 natural sciences Inferior mesenteric artery Article General Biochemistry Genetics and Molecular Biology BPC 157 03 medical and health sciences vascular recruitment 0302 clinical medicine Middle colic vein medicine.artery Internal medicine medicine Superior mesenteric artery Superior mesenteric vein Biology (General) superior mesenteric vein and artery occlusion rats business.industry medicine.disease Thrombosis Left colic vein 0104 chemical sciences 010404 medicinal & biomolecular chemistry medicine.anatomical_structure Cardiology cardiovascular system Inferior mesenteric vein Portal hypertension business 030217 neurology & neurosurgery |
| Zdroj: | Biomedicines, Vol 9, Iss 792, p 792 (2021) Biomedicines Volume 9 Issue 7 |
| Popis: | Background. We investigated the occluded essential vessel tributaries, both arterial and venous, occluded superior mesenteric vein and artery in rats, consequent noxious syndrome, peripherally and centrally. As therapy, we hypothesized the rapidly activated alternative bypassing pathways, arterial and venous, and the stable gastric pentadecapeptide BPC 157 since it rapidly alleviated venous occlusion syndromes. Methods. Assessments were performed for 30 min (gross recording, venography, ECG, pressure, microscopy, biochemistry, and oxidative stress), including portal hypertension, caval hypertension, aortal hypotension, and centrally, the superior sagittal sinus hypertension systemic arterial and venous thrombosis, ECG disturbances, MDA-tissue increase, the multiple organs lesions, heart, lung, liver, kidney and gastrointestinal tract, including brain (swelling, and cortex (cerebral, cerebellar), hypothalamus/thalamus, hippocampus lesions). Rats received BPC 157 medication (10 µg/kg, 10 ng/kg) intraperitoneally at 1 min ligation-time. Results. BPC 157 rapidly activated collateral pathways. These collateral loops were the superior mesenteric vein-inferior anterior pancreaticoduodenal vein-superior anterior pancreaticoduodenal vein-pyloric vein-portal vein pathway, an alternative pathway toward inferior caval vein via the united middle colic vein and inferior mesenteric vein through the left colic vein, and the inferior anterior pancreaticoduodenal artery and inferior mesenteric artery. Consequently, BPC 157 counteracted the superior sagittal sinus, portal and caval hypertension, aortal hypotension, progressing venous and arterial thrombosis peripherally and centrally, ECG disturbances attenuated. Markedly, the multiple organs lesions, heart, lung, liver, kidney, and gastrointestinal tract, in particular, as well as brain lesions, and oxidative stress in tissues were attenuated. Conclusions. BPC 157 therapy rapidly recovered rats, which have complete occlusion of the superior mesenteric vein and artery. |
| Databáze: | OpenAIRE |
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