Potential Drug Targets Against Hepatitis B Virus Based on Both Virus and Host Factors
| Autor: | Yong-Yong Zhang, Dan-Ping Chai, Yi-Hang Wu, Xiao-Ping Yu, Bing-Yi Zhang, Lipeng Qiu, Ye Zihong |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Drug Hepatitis B virus media_common.quotation_subject Clinical Biochemistry Genome Viral Drug resistance medicine.disease_cause Antiviral Agents Virus 03 medical and health sciences Hepatitis B Chronic 0302 clinical medicine Immune system Drug Resistance Viral Drug Discovery Animals Humans Medicine media_common Pharmacology Hepatitis Host Microbial Interactions business.industry Hepatitis B medicine.disease Virology Chronic infection 030104 developmental biology Molecular Medicine 030211 gastroenterology & hepatology business |
| Zdroj: | Current Drug Targets. 20:1636-1651 |
| ISSN: | 1389-4501 |
| Popis: | Background:Hepatitis B is a very harmful and epidemic disease caused by hepatitis B virus (HBV). Although an effective anti-HBV vaccine is available, chronic infection poses still a huge health burden in the whole world. The present anti-HBV drugs including nucleoside analogues and interferonalpha have their limitations without exception. There is no effective drug and therapeutic method that can really and truly cure hepatitis B so far. The variability of HBV genome results in that a significant number of patients develop drug resistance during the long-term use of anti-HBV drugs. Hence, it is urgently needed to discover novel targets and develop new drugs against hepatitis B.Objective:The review aims to provide the theory support for designing of the anti-HBV innovative drugs by offering a summary of the current situation of antiviral potential targets.Results and Conclusion:Since HBV is obligate intracellular parasite, and as such it depends on host cellular components and functions to replicate itself. The targeting both virus and host might be a novel therapeutic option for hepatitis B. Accordingly, we analyse the advances in the study of the potential drug targets for anti-HBV infection, focusing on targeting virus genome, on targeting host cellular functions and on targeting virus-host proteins interactions, respectively. Meanwhile, the immune targets against chronic hepatitis B are also emphasized. In short, the review provides a summary of antiviral therapeutic strategies to target virus factors, host factors and immune factors for future designing of the innovative drug against HBV infection. |
| Databáze: | OpenAIRE |
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