Holter Monitoring (24-Hour ECG) Parameter Dynamics in Patients with Ischemic Heart Disease and Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia

Autor: P V Glybochko, Phillip Yu. Kopylov, Leonid Rapoport, Dmitrii G. Tsarichenko, Andrey Vinarov, Dmitrii N. Fiev, Abram L. Syrkin, Yuri Demidko, Yuri Alyaev
Rok vydání: 2019
Předmět:
Male
Tamsulosin
medicine.medical_specialty
Urethral Obstruction
media_common.quotation_subject
medicine.medical_treatment
Urinary system
Voiding dysfunctions
Urology
Myocardial Ischemia
Prostatic Hyperplasia
Alpha-1-adrenoblockers
urologic and male genital diseases
Urination
Russia
Angina
Lower Urinary Tract Symptoms
Lower urinary tract symptoms
Medicine
Humans
Pharmacology (medical)
cardiovascular diseases
Cardiac rhythm
media_common
Transurethral resection of the prostate
Aged
Original Research
Transurethral resection of the prostate (TURP)
Aged
80 and over
Lower urinary tract symptoms (LUTS)
business.industry
Benign prostatic hyperplasia (BPH)
Ischemic heart disease (IHD)
General Medicine
Hyperplasia
Middle Aged
medicine.disease
Adrenergic alpha-1 Receptor Antagonists
Electrocardiography
Ambulatory
Urological Agents
Holter monitoring (HM)
business
medicine.drug
Zdroj: Advances in Therapy
ISSN: 1865-8652
Popis: Introduction This study examined the dynamics of 24-h electrocardiogram (ECG) monitoring parameters (Holter monitoring) in patients with ischemic heart disease (IHD) before and after conservative or surgical treatment of patients with voiding and storage lower urinary tract symptoms (LTS) due to benign prostatic hyperplasia (BPH). Methods A total of eighty-three 57 to 81-year-old (mean age 70.4 ± 5.75 years) patients with LUTS/BPH and accompanying IHD were examined and treated at the Institute of Urology and Human Reproductive Health and Clinic of Cardiology of Sechenov University. All patients received recommended cardiac therapy at least 6 months before inclusion in the study. Results Our study demonstrated that there is correlation between voiding and storage LUTS/BPH and Holter-detected cardiac impairments in patients with IHD/BPH. These data make it possible to consider LUTS/BPH (voiding and storage) as a factor in the additional functional and psychological load on the activity of patients with ischemic heart disease. Improvement of voiding and storage LUTS due to BPH and objective parameters of urination (Qmax) in patients treated with alpha-1 adrenoceptor blocker tamsulosin correlated with improvement of 24-h ECG monitoring parameters (Holter monitoring) in 72% of patients. Improvement of 24-h ECG monitoring parameters (Holter monitoring) 1 month after transurethral resection of the prostate (TURP) in IHD/BPH patients and indications for surgical treatment was observed in 65.7%. Negative dynamics of the Holter-based ECG was not registered in patients who were operated on. Conclusion Holter monitoring helps to identify groups of patients in whom urinary impairments caused by prostatic hyperplasia negatively affect the course of IHD. Restored urination (either conservatively or operatively) in patients with BPH in 72% of cases decreased the number of fits of angina, thus influencing favourably the course of IHD. Trial Registration ClinicalTrials.gov Identifier: NCT03856242.
Databáze: OpenAIRE
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