Making the connection – shared molecular machinery and evolutionary links underlie the formation and plasticity of occluding junctions and synapses
| Autor: | Simon Wang, Charles Krieger, Nicholas Harden |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Membranes Guanylate kinase Tight junction Septate junctions Cell Biology Biology Plasticity Biological Evolution Models Biological Epithelium Cell biology Synapse 03 medical and health sciences Intercellular Junctions 030104 developmental biology Paranodal junction Synapses Synaptic plasticity Pleated septate junction Animals Humans |
| Zdroj: | Journal of Cell Science. 129:3067-3076 |
| ISSN: | 1477-9137 0021-9533 |
| Popis: | The pleated septate junction (pSJ), an ancient structure for cell–cell contact in invertebrate epithelia, has protein components that are found in three more-recent junctional structures, the neuronal synapse, the paranodal region of the myelinated axon and the vertebrate epithelial tight junction. These more-recent structures appear to have evolved through alterations of the ancestral septate junction. During its formation in the developing animal, the pSJ exhibits plasticity, although the final structure is extremely robust. Similar to the immature pSJ, the synapse and tight junctions both exhibit plasticity, and we consider evidence that this plasticity comes at least in part from the interaction of members of the immunoglobulin cell adhesion molecule superfamily with highly regulated membrane-associated guanylate kinases. This plasticity regulation probably arose in order to modulate the ancestral pSJ and is maintained in the derived structures; we suggest that it would be beneficial when studying plasticity of one of these structures to consider the literature on the others. Finally, looking beyond the junctions, we highlight parallels between epithelial and synaptic membranes, which both show a polarized distribution of many of the same proteins – evidence that determinants of apicobasal polarity in epithelia also participate in patterning of the synapse. |
| Databáze: | OpenAIRE |
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