Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury
| Autor: | Jonas Frisén, David van Bruggen, Shupei Zhang, Chika Yokota, Sara B. Mulinyawe, Markus M. Hilscher, Petra Kukanja, Muge Altinkok, Elisa M. Floriddia, Enric Llorens-Bobadilla, João P. Gonçalves dos Santos, Mats Nilsson, Mário Grãos, Lu O. Sun, Gonçalo Castelo-Branco, Tânia Lourenço |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Encephalomyelitis Autoimmune Experimental Science Encephalomyelitis Central nervous system General Physics and Astronomy Mice Transgenic Biology Article General Biochemistry Genetics and Molecular Biology Corpus Callosum 03 medical and health sciences 0302 clinical medicine Glial development Mole medicine Animals Cell Lineage Progenitor cell lcsh:Science 10. No inequality Spinal cord injury Spinal Cord Injuries Mice Knockout Multidisciplinary Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Gene Expression Profiling General Chemistry medicine.disease Spinal cord Oligodendrocyte Axons Mice Inbred C57BL Gene expression profiling Oligodendroglia 030104 developmental biology medicine.anatomical_structure Spinal Cord Mice Inbred CBA lcsh:Q Female Single-Cell Analysis Neuroscience Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that distinct MOL populations have spatial preference in the mammalian central nervous system (CNS). We found that MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types 5 and 6 (MOL5/6) increase their contribution to the OL lineage with age in all analyzed regions. MOL2 and MOL5/6 also have distinct spatial preference in the spinal cord regions where motor and sensory tracts run. OL progenitor cells (OPCs) are not specified into distinct MOL populations during development, excluding a major contribution of OPC intrinsic mechanisms determining MOL heterogeneity. In disease, MOL2 and MOL5/6 present different susceptibility during the chronic phase following traumatic spinal cord injury. Our results demonstrate that the distinct MOL populations have different spatial preference and different responses to disease. The oligodendrocyte lineage is known for its transcriptional heterogeneity, but the functional consequences of this are unclear. Here, the authors show that distinct populations of mature oligodendrocytes have spatial preferences in the brain and spinal cord and show different responses to spinal cord injury. |
| Databáze: | OpenAIRE |
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