Challenges in hepatitis C elimination despite highly effective antiviral agents in patients with and without intravenous drug use
| Autor: | F. Hucke, Markus Peck-Radosavljevic, Kerstin Flatscher, Simona Bota, Christian Urak, Marcel Razpotnik |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Hepatitis C virus Hepacivirus 030204 cardiovascular system & hematology medicine.disease_cause Antiviral Agents 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Outpatient clinic 030212 general & internal medicine Substance Abuse Intravenous Retrospective Studies business.industry Retrospective cohort study General Medicine Hepatitis C Hepatitis C Chronic Hepatology medicine.disease Pharmaceutical Preparations Cohort Coinfection business Viral load |
| Zdroj: | Wiener klinische Wochenschrift. 133:641-646 |
| ISSN: | 1613-7671 0043-5325 |
| Popis: | To assess the adherence to treatment, sustained virologic response (SVR) rate, and reinfection rate in hepatitis C patients with and without intravenous drug use. This retrospective study included hepatitis C patients, evaluated and treated in our hepatology outpatient clinic between January 2014 and October 2019. The following information was extracted from the patient’s file: the presence of positive viral load for hepatitis C virus (HCV), active and recent (in the last 6 months) use of i.v. drugs, HCV genotype, treatment regimen, SVR, HCV reinfection rate, coinfection with human immunodeficiency virus (HIV) and ongoing opioid substitution therapy (OST). We included 431 hepatitis C patients, 234 people who inject drugs (PWID) and 197 non-PWID. Most patients were treated with direct-acting antivirals (DAA) only. The rate of documented SVR by treated patients was significantly higher in the non-PWID cohort (91.5% vs. 61.5%, p |
| Databáze: | OpenAIRE |
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