C1Q Complexes with Beta-2-Microglobulin and Amyloid P-Component in Sera of Patients with Dialysis-Associated Amyloidosis
| Autor: | Shirou Kawashima, Hiroshi Hassegawa, Hideki Katsumata, Kuniyoshi Kojima, Makoto Tomita, Toshiyuki Yanai, Masahiko Shikano, Midori Hasegawa, Naoto Kawamura, Kazutaka Murakami |
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| Rok vydání: | 1995 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Time Factors Amyloid medicine.medical_treatment Renal Dialysis immune system diseases Internal medicine medicine Amyloid precursor protein Humans skin and connective tissue diseases Dialysis medicine.diagnostic_test biology Beta-2 microglobulin business.industry Complement C1q Amyloidosis Middle Aged medicine.disease Serum Amyloid P-Component Endocrinology Immunoassay biology.protein Female Hemodialysis beta 2-Microglobulin Complication business |
| Zdroj: | Nephron. 69:380-383 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | We studied complexes composed of C1q and beta 2-microglobulin (C1q.beta 2M) or serum amyloid P-component (C1q.SAP) in the sera of 38 patients receiving hemodialysis (HD) and 20 healthy control subjects using an enzyme-linked immunoassay. We also compared complex levels in HD patients with and without symptoms of HD-associated amyloidosis (HA). Serum C1q-beta 2M levels were significantly higher in HD patients without HA than in healthy control subjects and significantly higher in HD patients with HA than in HD patients without HA. Serum C1q.SAP levels were significantly lower in patients with HA than in those without HA. These results suggest that C1q.beta 2M may contribute to HA. |
| Databáze: | OpenAIRE |
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