Plasma cell myeloma positive for t(14;20) with relapse in the central nervous system
| Autor: | Hiroshi Inagaki, Ayako Masaki, Shinsuke Iida, Ichiro Hanamura, Keiichiro Fujii, Takayuki Murase, Masaki Ri, Tomoko Narita, Atsushi Inagaki |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Cerebellum animal structures Central nervous system Chromosomes Human Pair 20 Chromosomal translocation Case Report Disease q11)/IGH-MAFB CNS Translocation Genetic Bortezomib 03 medical and health sciences 0302 clinical medicine Fatal Outcome Internal medicine Plasma Cell Myeloma medicine Humans skin and connective tissue diseases Chromosomes Human Pair 14 business.industry Cerebrum Brain Neoplasms General Medicine Middle Aged plasma cell myeloma t(14 20)(q32 medicine.anatomical_structure 030220 oncology & carcinogenesis Proteasome inhibitor Female business Multiple Myeloma 030215 immunology medicine.drug |
| Zdroj: | Journal of Clinical and Experimental Hematopathology : JCEH |
| ISSN: | 1880-9952 |
| Popis: | t(14;20)(q32;q11)/IGH-MAFB is a rare chromosomal abnormality in plasma cell myeloma (PCM), accounting for 1-2% of PCM cases. Patients with this translocation may have a poor prognosis. However, the clinicopathological features and response to novel agents have not been well clarified. We present a 63-year-old Japanese female with PCM positive for t(14;20). The tumor responded well to a proteasome inhibitor, bortezomib, and the patient achieved complete remission. Six months after remission, tumor relapse was noted in the left cerebellum and the right frontal lobe of the cerebrum. After whole brain radiation therapy, the tumor masses decreased in size. The patient was followed up with best-care support, but died of the disease 29 months after the initial PCM diagnosis. t(14;20)-positive PCM responded well to bortezomib at the time of the initial treatment. The CNS tumor involvement, which is rare in PCM, may be associated with the clinical aggressiveness of the t(14;20)-positive form of this myeloma. |
| Databáze: | OpenAIRE |
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