'Splitting the matrix': intussusceptive angiogenesis meets MT1‐MMP
| Autor: | Kairbaan Hodivala-Dilke, José M. Muñoz-Félix, Ana Rita Pedrosa, Gabriela D'Amico |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Medicine (General) Vascular Biology & Angiogenesis Immunology Regulator QH426-470 Matrix metalloproteinase Nitric Oxide Inflammatory bowel disease Nitric oxide Thrombospondin 1 03 medical and health sciences chemistry.chemical_compound Mice R5-920 0302 clinical medicine Genetics Matrix Metalloproteinase 14 Medicine Animals Humans News & Views Intussusceptive angiogenesis Neovascularization Pathologic business.industry Endothelial Cells medicine.disease Colitis Molecular medicine Endothelial stem cell Mice Inbred C57BL 030104 developmental biology chemistry Cancer research Molecular Medicine business Digestive System Intussusception 030217 neurology & neurosurgery |
| Zdroj: | EMBO Molecular Medicine EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020) |
| ISSN: | 1757-4684 1757-4676 |
| Popis: | Pathological angiogenesis contributes to tumour progression as well as to chronic inflammatory diseases. In this issue of EMBO Molecular Medicine, Esteban and co‐workers identify endothelial cell MT1‐MMP as a key regulator of intussusceptive angiogenesis (IA) in inflammatory colitis. Thrombospondin 1 (TSP1) cleavage by MT1‐MMP results in the binding of the c‐terminal fragment of TSP1 to αvβ3 integrin, which induces nitric oxide (NO) production, vasodilation and further initiation of IA. This novel control mechanism of inflammatory IA points towards promising new therapeutic targets for inflammatory bowel disease. Prof. Hodivala‐Dilke and colleagues discuss the findings from Esteban et al (in this issue of EMBO Molecular Medicine) that targeting intussusceptive angiogenesis via the TSP1‐nitric oxide axis exhibits therapeutic efficacy in the context of inflammatory bowel disease. |
| Databáze: | OpenAIRE |
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