Impact of TOTUM-63, a fibre and polyphenol rich plant-based composition, on gut and pancreatic hormone secretion in diet-induced obese mice
| Autor: | Vivien Chavanelle, Stéphanie Chanon, Claudie Pinteur, Emmanuelle Loizon, Guillaume Vial, Yolanda F. Otero, Florian Le Joubioux, Thierry Maugard, Sébastien L. Peltier, Pascal Sirvent, Béatrice Morio |
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| Přispěvatelé: | Valbiotis R & D [Riom], Valbiotis SAS, Partenaires INRAE-Partenaires INRAE, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Valbiotis R&D [Perigny], LIttoral ENvironnement et Sociétés (LIENSs), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS), Vial, Guillaume |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Blood Glucose
Male hormonal regulation Endocrinology Diabetes and Metabolism [SDV]Life Sciences [q-bio] Medicine (miscellaneous) Mice Obese Gastric Inhibitory Polypeptide Diet High-Fat Weight Gain Mice Glucagon-Like Peptide 1 Animals Humans Insulin glucose homeostasis Peptide YY Pyruvates Nutrition Nutrition and Dietetics enteroendocrine cells Plant Extracts Body Weight digestive oral and skin physiology Polyphenols Glucagon Mice Inbred C57BL [SDV] Life Sciences [q-bio] plant-based food supplement Metabolism and Cardiovascular Diseases glucose homeostasis Cardiology and Cardiovascular Medicine hormones hormone substitutes and hormone antagonists |
| Zdroj: | Nutrition, Metabolism and Cardiovascular Diseases Nutrition, Metabolism and Cardiovascular Diseases, 2022, 32 (7), pp.1797-1807. ⟨10.1016/j.numecd.2022.04.001⟩ |
| ISSN: | 0939-4753 |
| Popis: | International audience; Background and AimsTOTUM-63, a fibre and polyphenol rich plant-based composition, has been demonstrated to significantly improve body weight and glucose homeostasis in animal models of obesity. Our study aimed at exploring whether the mechanisms include modulation of gut (glucose-dependent insulinotropic peptide (GIP), glucagon-like petide-1 (GLP-1), cholecystokinin (CCK), peptide YY (PYY)) and pancreatic (insulin, glucagon) hormones, all important regulators of glucose control, appetite and body weight.Methods and ResultsMale C57BL/6JRJ mice were assigned to either standard chow (CON), high fat diet (HF, 60% energy from fat) or HF-TOTUM-63 (HF diet 60% supplemented with TOTUM-63 2.7%) for 10 weeks. In vivo glucose homeostasis (oral glucose tolerance test (OGTT), intraperitoneal pyruvate tolerance test (ipPTT)), glucose-induced portal vein hormone concentration, gut hormone gene expression and protein content as well as enteroendocrine cell contents were assessed at the end of the dietary intervention. The present study evidenced that TOTUM-63 reduced food intake, limited weight gain and improved glucose and pyruvate tolerance of HF-fed animals. This was associated with an increase in PYY content in the colon, an altered pattern of PYY secretion between fasted and glucose-stimulated states, and with a significant improvement in the portal vein concentration of GLP-1, insulin and glucagon, but not GIP and CCK, in response to glucose stimulation.ConclusionOverall, these data suggest that TOTUM-63 might have a specific impact on gut L-cells and on the expression and secretion of GLP-1 and PYY incretins, potentially contributing to the reduced food intake, body weight gain and improved glucose homeostasis. |
| Databáze: | OpenAIRE |
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