Evaluation of disintegrants functionality for orodispersible mini tablets

Autor: Bernard Bataille, Mohammad Chaheen, Tahmer Sharkawi, Nicolas Tarlier, Adrien Aubert, Ian Soulairol
Přispěvatelé: Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Université Libanaise
Rok vydání: 2017
Předmět:
Materials science
Calcium alginate
Chemistry
Pharmaceutical
Drug Compounding
superdisintegrants
Pharmaceutical Science
02 engineering and technology
[CHIM.THER]Chemical Sciences/Medicinal Chemistry
Orodispersible mini tablet
Friability
030226 pharmacology & pharmacy
Mini tablets
Excipients
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
In vivo
Tensile Strength
mini tablet characterization
Drug Discovery
Ultimate tensile strength
medicine
Cellulose
Porosity
disintegration time
Pharmacology
Organic Chemistry
Povidone
Starch
021001 nanoscience & nanotechnology
Carboxymethyl cellulose
Microcrystalline cellulose
chemistry
tabletability
Carboxymethylcellulose Sodium
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
0210 nano-technology
Tablets
Nuclear chemistry
medicine.drug
Zdroj: Drug Development and Industrial Pharmacy
Drug Development and Industrial Pharmacy, Taylor & Francis, 2017, 43 (11), pp.1770-1779. ⟨10.1080/03639045.2017.1339081⟩
ISSN: 0363-9045
1520-5762
DOI: 10.6084/m9.figshare.5132065.v1
Popis: Objective: This work evaluates the functionalities of different superdisintegrants (SD) for manufacturing orodispersible mini tablets (ODMT) by direct compression. Methods: Twenty-three formulations varying in SD type, concentration, and lubricant were used to manufacture ODMT. The ODMT were then characterized for the following properties: friability, porosity, tensile strength, in vivo and in vitro disintegration time (DT). Results: The results show that the presence, type, and concentration of SD did not influence friability, porosity, or tablet tensile strength. With regards to in vivo DT, only cross-linked poly (vinyl pyrrolidone) improved DT in all the tested formulations. Results also showed that when using microcrystalline cellulose (MCC) above 20% in the formulation, DT is longer. Cross-linked carboxymethyl cellulose accelerates DT when the MCC content is less than 20%. As for cross-linked carboxymethyl starch and calcium alginate showed no improvement on DT. Results for in vitro DT were all shorter than in vivo results and there was no correlation with the in vivo evaluation. Conclusions: This study shows that there is a need to develop better in vitro testing that precisely simulates in vivo conditions and that are adapted to ODMT. This standardization of the test methods for ODMTs must be accompanied by an improvement in the comprehension of SD mechanisms.
Databáze: OpenAIRE
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