Variable association of HLA-A2 in men with early-onset Alzheimer disease
| Autor: | Sandra C. Ebeling, Steven S. Matsuyama, Albert Heyman, Edward B. Renvoize, Emily G. Reisner, Gary W. Small, Raimo Sulkava |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Gerontology
Male Aging Human leukocyte antigen Early Onset Alzheimer Disease Disease 03 medical and health sciences 0302 clinical medicine Degenerative disease Sex Factors Alzheimer Disease HLA-A2 Antigen medicine Humans Association (psychology) Prospective cohort study Aged Aged 80 and over business.industry General Neuroscience Middle Aged medicine.disease Female Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease Age of onset business 030217 neurology & neurosurgery 030215 immunology Developmental Biology Demography |
| Zdroj: | Neurobiology of aging. 12(4) |
| ISSN: | 0197-4580 |
| Popis: | In the present study, we attempted to replicate the finding of an increased frequency of HLA-A2 in men with early-onset (less than or equal to 60 years) Alzheimer disease (AD). HLA data obtained on 167 patients (including 19 men with early-onset AD) from three geographic regions (North Carolina, Great Britain, and Finland) failed to replicate the result. A recent prospective study from Oregon, however, confirmed the association. Studies demonstrating the association suggest its presence in sporadic rather than familial AD. These results indicate a variable HLA/AD association, with some factor such as geographic region or disease familiality contributing to this variability. |
| Databáze: | OpenAIRE |
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