Marianins A and B, Prenylated Phenylpropanoids from Mariannaea camptospora
| Autor: | Fumihiro Fujimori, Toru Okuda, Takao Fukuda, Yuki Tsuchiya, Yasuhiro Igarashi, Yuri Sudoh |
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| Rok vydání: | 2011 |
| Předmět: |
Decarboxylation
Stereochemistry Pharmaceutical Science Microbial Sensitivity Tests Orcinol Analytical Chemistry chemistry.chemical_compound Drug Discovery Prenylation Pharmacology chemistry.chemical_classification Phenylpropionates biology Organic Chemistry biology.organism_classification Terpenoid Anti-Bacterial Agents Claisen rearrangement Micrococcus luteus Complementary and alternative medicine chemistry Hypocreales Molecular Medicine Antibacterial activity Derivative (chemistry) Lactone |
| Zdroj: | Journal of Natural Products. 74:1327-1330 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np200035m |
| Popis: | Marianins A (1) and B (2), two new prenylated phenylpropanoids, were isolated from the culture extract of the fungus Mariannaea camptospora. Structures of marianins were elucidated by interpretation of NMR and other spectroscopic data. 1 is a 5-methylcoumarin bearing two prenyloxy groups, while 2 is an orcinol derivative substituted with a 3,3-dimethyl-4-pentenoyl chain. 2 is possibly derived from 1 through a Claisen rearrangement of the prenyl group, followed by lactone hydrolysis and decarboxylation. These compounds showed weak antibacterial activity against Micrococcus luteus. |
| Databáze: | OpenAIRE |
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