Comparison of the renal effects of bisphenol A in mice with and without experimental diabetes. Role of sexual dimorphism
| Autor: | Paula Reventun, Carlos Zaragoza, María I. Arenas, Marta Saura, Nuria Olea-Herrero, Alba Antón-Cornejo, Rafael Moreno-Gómez-Toledano, Carmen Muñoz-Moreno, Adriana Izquierdo-Lahuerta, Marta González-Santander, Ricardo J. Bosch |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_specialty endocrine system Mouse Apoptosis Diabetic nephropathy Kidney Diabetes Mellitus Experimental Excretion chemistry.chemical_compound Mice Bisphenol A Lipocalin-2 Phenols Oral administration Internal medicine Diabetes mellitus medicine Animals Humans Diabetic Nephropathies Hepatitis A Virus Cellular Receptor 1 Benzhydryl Compounds Molecular Biology Creatinine Sex Characteristics business.industry urogenital system Diabetes medicine.disease Streptozotocin Sexual dimorphism medicine.anatomical_structure Endocrinology chemistry Hypertension Molecular Medicine Female business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria instname |
| Popis: | Bisphenol-A (BPA), a chemical -xenoestrogen- used in the production of the plastic lining of food and beverage containers, is present in the urine of almost the entire population. Recent studies have shown that BPA exposure is associated with podocytopathy, increased urinary albumin excretion (UAE), and hypertension. Since these changes are characteristic of early diabetic nephropathy (DN), we explored the renal effects of BPA and diabetes including the potential role of sexual dimorphism. Male and female mice were included in the following animals' groups: control mice (C), mice treated with 21.2 mg/kg of BPA in the drinking water (BPA), diabetic mice induced by streptozotocin (D), and D mice treated with BPA (D + BPA). Male mice form the D + BPA group died by the tenth week of the study due probably to hydro-electrolytic disturbances. Although BPA treated mice did not show an increase in serum creatinine, as observed in D and D + BPA groups, they displayed similar alteration to those of the D group, including increased in kidney damage biomarkers NGAL and KIM-1, UAE, hypertension, podocytopenia, apoptosis, collapsed glomeruli, as well as TGF-β, CHOP and PCNA upregulation. UAE, collapsed glomeruli, PCNA staining, TGF-β, NGAL and animal survival, significantly impaired in D + BPA animals. Moreover, UAE, collapsed glomeruli and animal survival also displayed a sexual dimorphism pattern. In conclusion, oral administration of BPA is capable of promoting in the kidney alterations that resemble early DN. Further translational studies are needed to clarify the potential role of BPA in renal diseases, particularly in diabetic patients. pre-print 3531 KB |
| Databáze: | OpenAIRE |
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