A Study on Molecular Mechanisms of Adiposis Induced by Long-Term Treatment of High-Fat and High-Sucrose in C57BL/6J Mice
| Autor: | Qiqi Liu, Muhammad Umar, Minggang Li, Wenya Luo, Jianghong Zhu, Xiaodan Li, Xingkai Yang, Peipei Tu, Deling Kong |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
DNA (Cytosine-5-)-Methyltransferase 1
Leptin Male 0301 basic medicine medicine.medical_specialty Time Factors Physiology Adipose tissue 030209 endocrinology & metabolism Biology Diet High-Fat DNA methyltransferase Mice 03 medical and health sciences 0302 clinical medicine Dietary Sucrose Internal medicine Gene expression medicine Animals Epigenetics Adiposity Glucose Transporter Type 4 Promoter General Medicine Methylation Mice Inbred C57BL 030104 developmental biology Endocrinology Adipose Tissue Liver DNMT1 |
| Zdroj: | Physiological Research. :75-87 |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.933830 |
| Popis: | Adiposis is reputed as a twin disease of type 2 diabetes and greatly harmful to human health. In order to understand the molecular mechanisms of adiposis, the changes of physiological, pathological, epigenetic and correlative gene expression were investigated during the adiposis development of C57BL/6J mice induced by long time (9 months) high-fat and high-sucrose diet (HFSD) sustainably. The results showed that mRNA transcription level of the Leptin, Glut4 and Glut2 genes have been obviously changed, which exhibit a negative correlation with methylation on their promoter DNA. The results also revealed that HFSD induced higher level of DNA methyltransferase 1 (DNMT1) in fat tissue might play important role in regulating the changes of methylation pattern on Glut4 and Leptin genes, and which might be one of the molecular mechanisms for the adiposis development. |
| Databáze: | OpenAIRE |
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