Antimicrobial resistance in Enterobacteriaceae in Brooklyn, NY: epidemiology and relation to antibiotic usage patterns
| Autor: | John Quale, Vivek M. Manikal, David Landman, Elise Oydna, Guillermo Saurina |
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| Rok vydání: | 2000 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Klebsiella pneumoniae Cephalosporin Drug resistance Microbial Sensitivity Tests Biology beta-Lactamases Microbiology Antibiotic resistance Enterobacteriaceae polycyclic compounds medicine Pulsed-field gel electrophoresis Escherichia coli Humans Pharmacology (medical) Proteus mirabilis Antibacterial agent Pharmacology Enterobacteriaceae Infections Drug Resistance Microbial biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Drug Utilization Anti-Bacterial Agents Infectious Diseases bacteria New York City |
| Zdroj: | The Journal of antimicrobial chemotherapy. 45(6) |
| ISSN: | 0305-7453 |
| Popis: | In November 1997, all Enterobacteriaceae isolated at 15 hospitals in Brooklyn were collected. Extended-spectrum beta-lactamases (ESBLs) were present in 44% of 409 Klebsiella pneumoniae isolates. Six isolates had reduced susceptibility to carbapenems, including two that were not susceptible to any of the antibiotics tested. Pulsed field gel electrophoresis revealed a commonality of resistant isolates within and between hospitals. The occurrence of ESBLcontaining isolates was associated with cephalosporin usage (P = 0.055). ESBLs were present in 4.7% of Escherichia coli and 9.5% of Proteus mirabilis isolates. It is concluded that ESBL-producing Enterobacteriaceae are endemic in Brooklyn, are spread between hospitals, and may be associated with cephalosporin usage. |
| Databáze: | OpenAIRE |
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