Clinical value of plasma B-type natriuretic peptide assay in pediatric pneumonia accompanied by heart failure
| Autor: | Yang Liu, Dan Hu, Jinping Gao, Huixian Tao |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty business.industry medicine.drug_class Cancer General Medicine Disease Articles medicine.disease Brain natriuretic peptide Gastroenterology Pneumonia Immunology and Microbiology (miscellaneous) Heart failure Internal medicine medicine Natriuretic peptide Clinical value Biomarker (medicine) business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Experimental and therapeutic medicine. 10(6) |
| ISSN: | 1792-0981 |
| Popis: | Previous studies have shown that B-type natriuretic peptide (BNP) is useful in differentiating cardiac from pulmonary causes of dyspnea in adults. To date, international guidelines have recommended measurements of circulating BNP as a biomarker for diagnostic and prognostic purposes, as well as therapeutic monitoring, in adults with cardiac diseases, particularly those suffering from acute and chronic heart failure (HF). The aim of the present study was to investigate the differential diagnostic and therapeutic analysis of BNP levels assayed in pediatric pneumonia accompanied by HF. The clinical data of 80 patients with pneumonia, aged 1-3 years, were analyzed. The patients were divided into two groups: Simple pneumonia (46 cases) and pneumonia accompanied by HF (34 cases). All patients underwent two plasma BNP assays: The first one upon admission to the hospital and the second one prior to discharge. The plasma BNP levels of 20 healthy children were used as the negative control. Plasma BNP levels were measured using the Triage® BNP automated immunoassay systems and reagents. Statistical analysis showed that the plasma BNP levels of the patients upon admission were higher in the pneumonia accompanied by HF group compared with those in the simple pneumonia group (750±120 vs. 135±50 pg/ml; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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