‘Magnesium’-the master cation-as a drug—possibilities and evidences
| Autor: | Aparna Ann Mathew, Rajitha Panonnummal |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Sodium
chemistry.chemical_element Calcium antagonist Calcium Pharmacology Article General Biochemistry Genetics and Molecular Biology Hypomagnesemia Biomaterials Cations Vasodilator medicine Magnesium NMDA blocker Metals and Alloys Glutamate receptor Forgotten cation medicine.disease chemistry Potassium NMDA receptor medicine.symptom General Agricultural and Biological Sciences Intracellular Muscle contraction |
| Zdroj: | Biometals |
| ISSN: | 1572-8773 0966-0844 |
| Popis: | Magnesium (Mg2+) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital biological functions. Magnesium (Mg2+) can regulate several cations, including sodium, potassium, and calcium; it consequently maintains physiological functions like impulse conduction, blood pressure, heart rhythm, and muscle contraction. But, it doesn’t get much attention in account with its functions, making it a “Forgotten cation”. Like other cations, maintenance of the normal physiological level of Mg2+ is important. Its deficiency is associated with various diseases, which point out to the importance of Mg2+ as a drug. The roles of Mg2+ such as natural calcium antagonist, glutamate NMDA receptor blocker, vasodilator, antioxidant and anti-inflammatory agent are responsible for its therapeutic benefits. Various salts of Mg2+ are currently in clinical use, but their application is limited. This review collates all the possible mechanisms behind the behavior of magnesium as a drug at different disease conditions with clinical shreds of evidence. |
| Databáze: | OpenAIRE |
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