Room Temperature Synthesis Mediated Porphyrinic NanoMOF Enables Benchmark Electrochemical Biosensing

Autor: Zhenyu Zhou, Jun Wang, Shujin Hou, Soumya Mukherjee, Roland A. Fischer
Rok vydání: 2023
Předmět:
Zdroj: Small.
ISSN: 1613-6829
1613-6810
Popis: Leveraging size effects, nanoparticles of metal-organic frameworks, nanoMOFs, have recently gained traction, amplifying their scopes in electrochemical sensing. However, their synthesis, especially under eco-friendly ambient conditions remains an unmet challenge. Herein, an ambient and fast secondary building unit (SBU)-assisted synthesis (SAS) route to afford a prototypal porphyrinic MOF, Fe-MOF-525 is introduced. Albeit the benign room temperature conditions, Fe-MOF-525(SAS) nanocrystallites obtained are of ≈30 nm size, relatively smaller than the ones conventional solvothermal methods elicit. Integrating Fe-MOF-525(SAS) as a thin film on a conductive indium tin oxide (ITO) surface affords Fe-MOF-525(SAS)/ITO, an electrochemical biosensor. Synergistic confluence of modular MOF composition, analyte-specific redox metalloporphyrin sites, and crystal downsizing contribute to its benchmark voltammetric uric acid (UA) sensing. Showcasing a wide linear range of UA detection with high sensitivity and low detection limit, this SAS strategy coalesces ambient condition synthesis and nanoparticle size control, paving a green way to advanced sensors.
Databáze: OpenAIRE
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