Quality of Life in NSCLC Survivors - A Multicenter Cross-Sectional Study
Autor: | Jan Stratmann, Thomas Wehler, Hubert Wirtz, Susanne Singer, Cornelius Kortsik, Roland Buhl, Heinz Schmidberger, Sebastian Wiesemann, Robert Bals, Maria Blettner, Jessica Peuser, Marlene Hechtner, Martin Sebastian, Bernhard Gohrbandt, Ursula Nestle, Beatrice Wehler, Martin Eichler |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Adult Male medicine.medical_specialty Lung Neoplasms Cross-sectional study Population 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine Carcinoma Non-Small-Cell Lung Surveys and Questionnaires Medicine Humans Survivors Lung cancer education Aged Aged 80 and over education.field_of_study business.industry Cancer Middle Aged medicine.disease Prognosis Combined Modality Therapy humanities Survival Rate 030104 developmental biology Cross-Sectional Studies Oncology Multicenter study 030220 oncology & carcinogenesis Quality of Life Patient-reported outcome Female Active treatment business Follow-Up Studies |
Zdroj: | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 14(3) |
ISSN: | 1556-1380 |
Popis: | The objective was to assess quality of life (QoL) in lung cancer survivors, compare it to the general population, and identify factors associated with global QoL, physical functioning, emotional functioning, fatigue, pain, and dyspnea.Data from NSCLC patients who had survived 1 year or longer after diagnosis were collected cross-sectionally in a multicenter study. QoL was assessed with the European Organisation for the Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-C30 and the lung cancer module QLQ-LC13 across different clinical subgroups and compared to age- and sex-standardized general population reference values. Multivariable linear regression analyses were performed to test the associations of patient-, tumor-, and treatment-related factors with the six primary QoL scales.Six hundred fifty-seven NSCLC patients participated in the study with a median time since diagnosis of 3.7 years (range, 1.0-21.2 years). Compared to the age- and sex-standardized general population, clinically meaningful differences in the QoL detriment were found on almost all domains: lung cancer survivors had clinically relevant poorer global QoL (10 points, p0.001). Whereas in 12 months or longer treatment-free patients this detriment was small (8.3), it was higher in patients currently in treatment (16.0). Regarding functioning and symptom scales, respective detriments were largest for dyspnea (41 points), role function (33 points), fatigue (27 points), social function (27 points), physical function (24 points), and insomnia (21 points) observed across all subgroups. The main factor associated with poorer QoL in all primary QoL scales was mental distress (β |19-31|, all p0.001). Detriments in QoL across multiple primary QoL scales were also observed with current treatment (β |8-12|, p0.01), respiratory comorbidity (β |4-5|, p0.01), and living on a disability pension (β |10-11|, p0.01). The main factor associated with better QoL in almost all primary QoL scales was higher physical activity (β |10-20|, p0.001). Better QoL was also observed in patients with high income (β |10-14|, p0.01).Lung cancer survivors experience both functional restrictions and symptoms that persist long term after active treatment ends. This substantiates the importance of providing long-term supportive care. |
Databáze: | OpenAIRE |
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