Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation

Autor: Sara Keränen, Doug Marchuk, Santeri Suutarinen, Timo Krings, Diana E. Guo, Juhana Frösen, Michael T. Lawton, Rahul Mallick, Johanna P. Laakkonen, Marie E. Faughnan, Seppo Ylä-Herttuala, Behnam Rezai Jahromi, Ivan Radovanovic, Timo Koivisto, Helen Kim, Ludmila Pawlikowska, Tuomas Rauramaa
Přispěvatelé: Tampere University, Clinical Medicine, Department of Musculoskeletal Diseases
Rok vydání: 2021
Předmět:
Intracranial Arteriovenous Malformations
Pathology
medicine.medical_specialty
Clinical Sciences
Lumen (anatomy)
Original Article - Vascular Neurosurgery - Arteriovenous malformation
Intracranial hemorrhage
Inflammation
macromolecular substances
Vascular Remodeling
030204 cardiovascular system & hematology
Cardiovascular
03 medical and health sciences
0302 clinical medicine
Mediator
medicine.artery
medicine
Humans
2.1 Biological and endogenous factors
Aetiology
Prostaglandin E2
Receptor
Neurology & Neurosurgery
business.industry
Brain arteriovenous malformation
Neurosciences
food and beverages
Brain
Vessel remodeling
3126 Surgery
anesthesiology
intensive care
radiology
Real-time polymerase chain reaction
Cyclooxygenase 2
Cyclo-oxygenase-2
Immunohistochemistry
Surgery
Neurology (clinical)
medicine.symptom
business
Non-steroidal anti-inflammatory drugs
030217 neurology & neurosurgery
Circle of Willis
medicine.drug
Zdroj: Acta neurochirurgica, vol 163, iss 9
Acta Neurochirurgica
ISSN: 0942-0940
0001-6268
DOI: 10.1007/s00701-021-04895-z
Popis: Background Brain arteriovenous malformations (bAVM) may rupture causing disability or death. BAVM vessels are characterized by abnormally high flow that in general triggers expansive vessel remodeling mediated by cyclo-oxygenase-2 (COX2), the target of non-steroidal anti-inflammatory drugs. We investigated whether COX2 is expressed in bAVMs and whether it associates with inflammation and haemorrhage in these lesions. Methods Tissue was obtained from surgery of 139 bAVMs and 21 normal Circle of Willis samples. The samples were studied with immunohistochemistry and real-time quantitative polymerase chain reaction (RT-PCR). Clinical data was collected from patient records. Results COX2 expression was found in 78% (109/139) of the bAVMs and localized to the vessels’ lumen or medial layer in 70% (95/135) of the bAVMs. Receptors for prostaglandin E2, a COX2-derived mediator of vascular remodeling, were found in the endothelial and smooth muscle cells and perivascular inflammatory cells of bAVMs. COX2 was expressed by infiltrating inflammatory cells and correlated with the extent of inflammation (r = .231, p = .007, Spearman rank correlation). COX2 expression did not associate with haemorrhage. Conclusion COX2 is induced in bAVMs, and possibly participates in the regulation of vessel wall remodelling and ongoing inflammation. Role of COX2 signalling in the pathobiology and clinical course of bAVMs merits further studies.
Databáze: OpenAIRE
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