α1L-Adrenoceptors mediate noradrenaline-induced contractions of the guinea-pig prostate stroma
| Autor: | Margot E Story, Winnie Ak Lau, Sabatino Ventura, Jocelyn N Pennefather, Christina Chin |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Tamsulosin medicine.medical_specialty Indoles Adrenergic receptor Hydrochloride Guinea Pigs In Vitro Techniques Biology Dioxanes Guinea pig Norepinephrine chemistry.chemical_compound Prostate Receptors Adrenergic alpha-1 Internal medicine medicine Prazosin Animals Adrenergic alpha-Antagonists Pharmacology Sulfonamides Dose-Response Relationship Drug Muscle Smooth Smooth muscle contraction Endocrinology medicine.anatomical_structure chemistry Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-1 Receptor Agonists medicine.symptom Adrenergic alpha-Agonists Muscle Contraction medicine.drug Muscle contraction |
| Zdroj: | European Journal of Pharmacology. 384:25-30 |
| ISSN: | 0014-2999 |
| Popis: | The alpha(1)-adrenoceptor subtype mediating noradrenaline-induced contractions of the guinea-pig isolated prostatic smooth muscle was investigated. Noradrenaline produced concentration-dependent contractions of the tissue with a mean pD(2) value of 5.26+/-0.03 (n=20). These contractions were antagonised by prazosin, 2-(2, 6-dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane hydrochloride (WB-4101), N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride (RS-17053) and (R)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]-2-methylethyl]-2- methoxybenzensulfonamide methanesulphonate hydrate (tamsulosin). Mean pA(2) or apparent pK(B) estimates for the antagonism of noradrenaline were 8.15+/-0.05 for prazosin; 8.83+/-0.11 for WB-4101, 7.18+/-0.14 for RS-17053 and 10.11+/-0.12 for tamsulosin. The relatively low estimates of the apparent dissociation constant for all antagonists except tamsulosin indicate that an alpha(1L)-adrenoceptor mediates noradrenaline-induced prostatic smooth muscle contraction in the guinea-pig prostate gland. |
| Databáze: | OpenAIRE |
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