Functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats
| Autor: | Bruna Calvo Agustinho, Anacharis Babeto de Sá-Nakanishi, Lucelia de Moura Pereira, Cecilia Edna Mareze da Mareze-da-Costa, Lúcia Maria Zeoula, Emerson Henri Yoshimura, Sílvia Cristina de Aguiar, Nadine Woruby Santos, Erica Machado |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male Physiology lcsh:Medicine 030204 cardiovascular system & hematology Biochemistry Antioxidants Fats Endocrinology 0302 clinical medicine Medicine and Health Sciences Food science lcsh:Science chemistry.chemical_classification Multidisciplinary Organic Compounds Chemistry Fatty Acids Monosaccharides food and beverages Lipids Body Fluids Milk Physiological Parameters Physical Sciences Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Anatomy Research Article Polyunsaturated fatty acid medicine.drug Endocrine Disorders Carbohydrates 030209 endocrinology & metabolism Mesenteric fat Body weight Diabetes Mellitus Experimental Beverages Cow milk 03 medical and health sciences Diabetes mellitus Diabetes Mellitus medicine Animals Nutrition Body Weight Organic Chemistry lcsh:R Chemical Compounds Polyphenols Biology and Life Sciences Streptozotocin medicine.disease Animal Feed Rats Diet Normal group Glucose Polyphenol Metabolic Disorders Cattle lcsh:Q Biomarkers |
| Zdroj: | PLoS ONE, Vol 13, Iss 4, p e0195839 (2018) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The increasing incidence of diabetes mellitus is becoming a serious threat to human health in various parts of the world. Studies with dairy products have shown a potential beneficial effect against diabetes. This experiment evaluated the supplementation of milk naturally enriched with polyunsaturated fatty acids (PUFA) and polyphenols in rats with streptozotocin-induced diabetes. Forty male 28-day-old Wistar rats were distributed in four experimental treatments of diabetic animals (streptozotocin induction) and a normal group (non-induced). Experimental treatments were: control (water), whole common milk (COM-M), milk enriched with PUFA (PUFA-M), milk enriched with PUFA and polyphenols (PUFA/P-M) through a special diet offered to dairy cows. Milk supplementation at a dose 5 mL/kg body weight was performed for 77 days, 42 days before and 35 days after diabetes induction. The COM-M supplementation increased brown fat deposits, reduced post-induction glucose levels, reduced blood fructosamine levels, and improved glucose tolerance. Milk enriched with PUFA reduced final fasting glucose, LDL levels, and improved blood antioxidant capacity. Milk enriched with PUFA and polyphenols promoted an increase in gastrocnemius muscle mass, and a reduction in mesenteric fat and LDL levels. Milk intake, with an emphasis on milk enriched with PUFA and polyphenols, attenuated the metabolic disorders of streptozotocin-induced diabetes in rats. |
| Databáze: | OpenAIRE |
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