Central Venous Catheter Thrombosis in Cancer: A Multi-Centre Retrospective Study Investigating Risk Factors and Contemporary Trends in Management
| Autor: | Gurdeep Parmar, Lucy Haggstrom, Daniel Brungs |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Central Venous Catheter Thrombosis Colorectal cancer medicine.medical_treatment pancreatic cancer colorectal cancer 030204 cardiovascular system & hematology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Adverse event management Pancreatic cancer medicine acute lymphocytic leukaemia (ALL) Chemotherapy business.industry General surgery gastric cancer Cancer Retrospective cohort study medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Thrombosis Oncology 030220 oncology & carcinogenesis acute myeloid leukaemia (AML) Original Article business |
| Zdroj: | Clinical Medicine Insights. Oncology Clinical Medicine Insights: Oncology, Vol 14 (2020) |
| ISSN: | 1179-5549 |
| Popis: | Objectives: Central venous access is needed to facilitate chemotherapy for many cancer patients. Central venous catheter-related thrombosis (CVCT) is a major complication that can cause significant morbidity and mortality. We sought to explore the rate of CVCT in a general cancer population in Australia and to identify factors associated with increased risk of thrombosis. Design: This is a multi-centre retrospective cohort study. Setting and participants: We analysed key patient, treatment, and cancer-related factors for 317 patients with cancer and central venous catheters inserted for systemic therapy. Main outcome measures: Symptomatic CVCT confirmed with imaging and management of patients with CVCT. Results: A total of 402 cases of central line insertion were analysed. Central venous catheter-related thrombosis occurred in 24 patients (6.0%). Having a peripherally inserted central catheter (PICC; HR = 3.78, 95% CI = 1.28-11.19, P = .02) compared with an implantable port and a body mass index of ⩾25.0 kg/m2 (HR = 3.60, 95% CI = 1.31-9.85, P = .01) were independently associated with increased risk of thrombosis. Central venous catheter-related thrombosis was managed mostly with removal of the catheter (19 of 24 cases) and anticoagulation, including direct-acting oral anticoagulants in 5 patients. Conclusions: This work explored rates of CVCT in a general cancer population, observing increased rates in those with PICCs or increased body mass index. |
| Databáze: | OpenAIRE |
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