The Interplay of RNA Binding Proteins, Oxidative Stress and Mitochondrial Dysfunction in ALS
| Autor: | Benjamin E. Clarke, Rickie Patani, Jasmine Harley |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Physiology Clinical Biochemistry RNA-binding protein Review medicine.disease_cause Biochemistry 03 medical and health sciences 0302 clinical medicine Gene expression mitochondrial dysfunction medicine oxidative stress Amyotrophic lateral sclerosis Molecular Biology Chemistry lcsh:RM1-950 Cell Biology medicine.disease RNA binding protein Cell biology 030104 developmental biology lcsh:Therapeutics. Pharmacology ALS 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Antioxidants, Vol 10, Iss 552, p 552 (2021) Antioxidants |
| ISSN: | 2076-3921 |
| Popis: | RNA binding proteins fulfil a wide number of roles in gene expression. Multiple mechanisms of RNA binding protein dysregulation have been implicated in the pathomechanisms of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Oxidative stress and mitochondrial dysfunction also play important roles in these diseases. In this review, we highlight the mechanistic interplay between RNA binding protein dysregulation, oxidative stress and mitochondrial dysfunction in ALS. We also discuss different potential therapeutic strategies targeting these pathways. |
| Databáze: | OpenAIRE |
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