Antimicrobial susceptibility and genetic features of a heterogeneous vancomycin intermediate-resistant Staphylococcus aureus strain
| Autor: | Yuzhu Mao, Xuerui Bao, Bing Li, Thanapop Soteyome, Lin Li, Wenyi Xu, Ling Yang, Liting Wan, Zerong Lu, Zhenbo Xu, Congxiu Ye, Dingqiang Chen, Janette M. Harro |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) China Staphylococcus aureus Virulence Factors 030106 microbiology Virulence Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Genome 03 medical and health sciences Minimum inhibitory concentration Antibiotic resistance Vancomycin Genetics medicine Humans Molecular Biology Gene Ecology Evolution Behavior and Systematics Vancomycin Resistance Genomics Staphylococcal Infections Antimicrobial Anti-Bacterial Agents 030104 developmental biology Infectious Diseases Female Genome Bacterial medicine.drug |
| Zdroj: | Infection, Genetics and Evolution. 85:104565 |
| ISSN: | 1567-1348 |
| DOI: | 10.1016/j.meegid.2020.104565 |
| Popis: | This study aimed to characterize the antimicrobial susceptibility and genetic features of a heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) strain Guangzhou-SauVS2 recovered from a female patient in Guangzhou, representative of southern China. The genome of Guangzhou-SauVS2 was sequenced using Illumina HiSeq 2500 platform and assembled de novo using Velvet v1.2.08. Annotations and bioinformatics analysis were further performed. Results showed that Guangzhou-SauVS2 was susceptible and resistant to 7 and 11 antibiotic drugs, respectively, and exhibited hVISA with a minimum inhibitory concentration of vancomycin as 4 μg/mL. Its genome is 2,883,941 bp in length and contains 2934 predicted genes with an average G + C content of 32.9%. Besides, a total of 38 virulence factors and 4 antibiotic-resistant genes were identified. These results can be employed to further study the pathogenic and antimicrobial mechanisms of hVISA |
| Databáze: | OpenAIRE |
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