In Situ Gelling Pectin Formulations for Oral Sustained Delivery of Paracetamol

Autor:	Yasuhiro Konno, Wataru Kubo, Shozo Miyazaki, David Attwood
Rok vydání:	2004
Předmět:	Male food.ingredient Pectin Chemistry Pharmaceutical Analgesic Administration Oral Biological Availability Pharmaceutical Science chemistry.chemical_element In Vitro Techniques Pharmacology Calcium Excipients food Oral administration Drug Discovery medicine Animals Antipyretic Rats Wistar Acetaminophen Aqueous solution Chromatography Chemistry digestive oral and skin physiology Organic Chemistry Water Rats Bioavailability Pharmaceutical Solutions Delayed-Action Preparations Pectins Calcium Citrate Gels medicine.drug
Zdroj:	Drug Development and Industrial Pharmacy. 30:593-599
ISSN:	1520-5762 0363-9045
Popis:	The purpose of this study was to evaluate the potential of a pectin formulation with in situ gelling properties for the oral sustained delivery of paracetamol (acetaminophen). The formulations consisted of dilute aqueous solutions (1% to 2% w/v) of low methoxy pectin containing calcium ions in complexed form, which on release in the acidic environment of the stomach caused gelation of the pectin. In vitro studies demonstrated diffusion-controlled release of paracetamol from the gels over a period of 6 h. A bioavailability of approximately 96% of that of a paracetamol solution could be achieved from gels containing an identical dose of drug formed in situ in the stomachs of rats, with appreciably lower peak plasma levels and a sustained release of drug over a period of at least 6 h.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c18d940f5c65e8a4c70fa56987af87 https://doi.org/10.1081/ddc-120037490 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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