Differentiation between active and chronic Crohn's disease using MRI small-bowel motility examinations - initial experience
| Autor: | Roger Cattin, Radu Tutuian, Johannes M. Froehlich, H. Bouquet, Stephan Raible, K.U. Wentz, N. Patuto, Michael A. Patak, J.L. Culmann, Sebastian Bickelhaupt, U. Bill |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Motility Magnetic Resonance Imaging Cine Disease Gastroenterology Young Adult Small bowel motility Crohn Disease Ileum Internal medicine Occlusion Intestine Small medicine Humans Radiology Nuclear Medicine and imaging Aged Retrospective Studies Aged 80 and over Crohn's disease medicine.diagnostic_test business.industry Magnetic resonance imaging Retrospective cohort study General Medicine Middle Aged medicine.disease digestive system diseases Surgery Case-Control Studies Female Analysis of variance business Gastrointestinal Motility |
| Zdroj: | Clinical radiology. 68(12) |
| ISSN: | 1365-229X |
| Popis: | AIM: To evaluate the influence of locally active Crohn's disease on systemic small-bowel motility in patients with chronic Crohn's disease compared to healthy individuals. MATERIAL AND METHODS: Fifteen healthy individuals (11 men, four women; mean age 37 years) and 20 patients with histopathologically proven active (n = 15; 10 women, 5 men; mean age 45 years) or chronic (n = 5; four women, one man; mean age 48 years) Crohn's disease were included in this institutional review board-approved, retrospective study. Magnetic resonance imaging (MRI; 1.5 T) was performed after standardized preparation. Two-dimensional (2D) cine sequences for motility acquisition were performed in apnoea (27 s). Motility assessment was performed using dedicated software in three randomly chosen areas of the small-bowel outside known Crohn's disease-affected hotspots. The main quantitative characteristics (frequency, amplitude, occlusion rate) were compared using Student's t-test and one-way analysis of variance (ANOVA). RESULTS: Three randomly chosen segments were analysed in each participant. Patients with active Crohn's disease had significantly (p < 0.05) reduced contraction frequencies (active Crohn's disease: 2.86/min; chronic: 4.14/min; healthy: 4.53/min) and luminal occlusion rates (active: 0.43; chronic: 0.70; healthy: 0.73) compared to healthy individuals and patients with chronic Crohn's disease. Contraction amplitudes were significantly reduced during active Crohn's disease (6.71 mm) compared to healthy participants (10.14 mm), but this only reached borderline significance in comparison to chronic Crohn's disease (8.87 mm). Mean bowel lumen diameter was significantly (p = 0.04) higher in patients with active Crohn's disease (16.91 mm) compared to healthy participants (14.79 mm) but not in comparison to patients with chronic Crohn's disease (13.68). CONCLUSION: The findings of the present study suggest that local inflammatory activity of small-bowel segments in patients with active Crohn's disease alters small-bowel motility in distant, non-affected segments. The motility patterns revealed reduced contraction-wave frequencies, amplitudes, and decreased luminal occlusion rates. Thus evaluation of these characteristics potentially helps to differentiate between chronic and active Crohn's disease. |
| Databáze: | OpenAIRE |
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