CT Screening for Lung Cancer: Suspiciousness of Nodules according to Size on Baseline Scans
| Autor: | David F. Yankelevitz, James P. Smith, David P. Naidich, Mark W. Pasmantier, Daniel M. Libby, Claudia I. Henschke, Olli S. Miettinen, Dorothy I. McCauley, Georgeann McGuinness |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms New York Malignancy Computed tomographic Diagnosis Differential Cancer screening Biopsy medicine Humans Mass Screening Radiology Nuclear Medicine and imaging Lung cancer Aged Neoplasm Staging Retrospective Studies medicine.diagnostic_test business.industry Solitary Pulmonary Nodule Nodule (medicine) Middle Aged medicine.disease Ct screening Lung disease Female Radiology medicine.symptom Tomography X-Ray Computed Nuclear medicine business Follow-Up Studies |
| Zdroj: | Radiology. 231:164-168 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiol.2311030634 |
| Popis: | To assess the frequency with which a particular, possibly optimal work-up of noncalcified nodules less than 5.0 mm in diameter identified on initial computed tomographic (CT) images at baseline screening leads to a diagnosis of malignancy prior to first annual repeat screening, compared with a possibly optimal work-up of larger nodules.Two series of baseline CT screenings in high-risk people were retrospectively reviewed. The first series (n = 1,000) was performed in 1993-1998; the second (n = 1,897), in 1999-2002. In each series, cases in which the largest noncalcified nodule detected was less than 5.0 mm in diameter and those in which it was 5.0-9 mm were reviewed to determine whether diagnostic work-up prior to first annual repeat screening showed or would have shown nodule growth and led or would have led to a diagnosis based on biopsy or surgical specimens.The frequency with which malignancy was or could have been diagnosed when the largest noncalcified nodule was less than 5.0 mm in diameter was 0 of 378, whereas when the largest noncalcified nodule was 5.0-9 mm in diameter, the frequency was 13 or 14 of 238. If persons with only nodules smaller than 5.0 mm had merely been referred for first annual repeat screening without immediate further work-up, the referrals for such work-up would have been reduced by 54% (from 817 [28%] to 385 [13%] of 2,897).In modern CT screening for lung cancer at baseline, detected noncalcified nodules smaller than 5.0 mm in diameter do not justify immediate work-up but only annual repeat screening to determine whether interim growth has occurred. |
| Databáze: | OpenAIRE |
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