Measuring steroids in hair opens up possibilities to identify congenital adrenal hyperplasia in developing countries
| Autor: | Selma Waaijers, Agustini Utari, Rick H. A. van der Doelen, Sultana M. H. Faradz, Renate Hensen‐Lodewijk, Andre J. Olthaar, Paul J. Geutjes, Fred C. Sweep, Hedi L. Claahsen‐van der Grinten, Antonius E. van Herwaarden |
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| Rok vydání: | 2023 |
| Předmět: |
Endocrinology
All institutes and research themes of the Radboud University Medical Center Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17] Adrenal Hyperplasia Congenital Indonesia Endocrinology Diabetes and Metabolism Humans Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16] Steroids Testosterone Hair Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] |
| Zdroj: | Clinical Endocrinology, 98, 41-48 Clinical Endocrinology, 98, 1, pp. 41-48 |
| ISSN: | 0300-0664 |
| Popis: | Contains fulltext : 291170.pdf (Publisher’s version ) (Open Access) OBJECTIVE: Patients with congenital adrenal hyperplasia (CAH) in developing countries have limited access to appropriate laboratory facilities for diagnosis and follow-up. The aim of this study is to evaluate steroid measurement in hair as a diagnostic tool to identify and monitor CAH in these patients. DESIGN: A method was developed to measure steroids in hair, the stability of steroids in hair was assessed, and the concentration range in healthy volunteers was determined. Hair samples of patients, before and after starting therapy, were transported at ambient temperature to The Netherlands for analysis. PATIENTS: Twenty-two Indonesian CAH patients and 84 healthy volunteers participated. MEASUREMENTS: Cortisol, 17-hydroxyprogesterone (17OHP), androstenedione, and testosterone in hair were measured by liquid chromatography with tandem mass spectrometry. RESULTS: Steroids in hair could be measured and remained stable ( |
| Databáze: | OpenAIRE |
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