Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats
Autor: | Mohamed I. S. Abdelhady, Mazen Gaith, Ahmad M. Ashshi, Naeem Qusty, Thalat Bokhary, Nagwa AlTaweel, Mohamed El-Boshy |
---|---|
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Male Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment 010501 environmental sciences Pharmacology medicine.disease_cause 01 natural sciences Antioxidants Transaminase Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Cynara scolymus medicine Environmental Chemistry Animals Rats Wistar 0105 earth and related environmental sciences chemistry.chemical_classification biology Superoxide Dismutase Glutathione peroxidase General Medicine Glutathione Malondialdehyde Catalase Pollution Interleukin-10 Rats Oxidative Stress 030104 developmental biology chemistry Biochemistry biology.protein Oxidative stress Cadmium |
Zdroj: | Environmental science and pollution research international. 24(13) |
ISSN: | 1614-7499 |
Popis: | Our objective was to explore the protective effect of artichoke leaf extract (ALE) against cadmium (Cd) toxicity-induced oxidative organ damage in rats. Male albino Wistar rats were divided into four equal groups of eight animals each. The first group was assigned as a control. Groups 2–4 were orally administered with ALE (300 mg/kg bw), Cd (CdCl2, 100 mg/L drinking water), and ALE plus Cd, respectively, daily for 4 weeks. After treatment with Cd, the liver and kidney malondialdehyde (MDA) increased significantly compared with the control rats. The sera interleukin (IL)-1β, tumor necrosis factor (TNF-α), and IL-10, liver transaminase, urea, creatinine, and peripheral neutrophil count were significantly increased in Cd-exposed rats compared to the control group. The reduced glutathione (GSH), glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) decreased in the liver and kidney in Cd-exposed group. In combination treatment, Cd and ALE significantly improved immune response, an antioxidant system, and hepatorenal function with a significant decline in MDA. In conclusion, ALE ameliorates the immunosuppressive and hepatorenal oxidative injury stimulated by Cd in rats. These results suggest that artichoke has shown promising effects against adverse effects of Cd toxicity. |
Databáze: | OpenAIRE |
Externí odkaz: |