The role of epigenetics in malignant pleural mesothelioma
| Autor: | Luc Willems, Fabian Vandermeers, Roland Hubaux, Jean-Philippe Cosse, Sathya Neelature Sriramareddy, Chrisostome Costa |
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| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
Epigenomics Mesothelioma Cancer Research Lung Neoplasms medicine.medical_treatment Pleural Neoplasms Antineoplastic Agents medicine.disease_cause Asbestos Epigenesis Genetic medicine Humans Epigenetics Cancer epigenetics DNA (Cytosine-5-)-Methyltransferases Chemotherapy Clinical Trials as Topic biology business.industry Mesothelioma Malignant Cancer respiratory system medicine.disease respiratory tract diseases Gene Expression Regulation Neoplastic Histone Deacetylase Inhibitors Histone Cell Transformation Neoplastic Oncology DNA methylation Immunology biology.protein Cancer research business |
| Zdroj: | Lung cancer (Amsterdam, Netherlands). 81(3) |
| ISSN: | 1872-8332 |
| Popis: | Malignant pleural mesothelioma (MPM) is an almost invariably fatal cancer of the pleura due to asbestos exposure. Increasing evidence indicates that unresponsiveness to chemotherapy is due to epigenetic errors leading to inadequate gene expression in tumor cells. The availability of compounds that modulate epigenetic modifications, such as histone acetylation or DNA methylation, offers new prospects for treatment of MPM. Here, we review latest findings on epigenetics in mesothelioma and present novel strategies for promising epigenetic therapies. |
| Databáze: | OpenAIRE |
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