Effects of Treatment Adherence on Quality of Life in Hypoparathyroid Patients
| Autor: | Ziynet Alphan Uc, Gulsah Elbuken, Gulay Simsek Bagir, Gülhan Duman, Guzide Gonca Oruk, Ozlem Celik, Goknur Yorulmaz, Masum Canat, Seda Sancak, Guzin Fidan Yaylali, Filiz Eksi Haydardedeoglu, Merve Yılmaz, Mazhar Müslüm Tuna, Seckin Akcay, Dilek Tuzun, Betul Ekiz Bilir, Gulhan Akbaba, Humeyra Bozoglan, Murat Topbaş, Emin Murat Akbas, Suheyla Gorar, Inan Anaforoglu, Kadriye Aydın Tezcan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty conventional treatment Turkey Treatment adherence Hypoparathyroidism Endocrinology Diabetes and Metabolism Beck Anxiety Inventory 030209 endocrinology & metabolism Disease psychology Anxiety treatment adherence Medication Adherence 03 medical and health sciences 0302 clinical medicine Endocrinology Quality of life turkey (bird) Internal medicine middle aged Outcome Assessment Health Care Internal Medicine medicine Humans human Prospective Studies Depression (differential diagnoses) business.industry Depression medication compliance Beck Depression Inventory clinical trial General Medicine medicine.disease female multicenter study quality of life 030220 oncology & carcinogenesis medicine.symptom business prospective study |
| DOI: | 10.1055/a-1400-2668 |
| Popis: | This study aimed to evaluate the current situation of hypoparathyroid patients and to investigate the relationship between treatment adherence and quality of life.Prospective, multicentre study.Adult patients presenting with the diagnosis of hypoparathyroidism to 20 different endocrinology clinics were included. They were receiving conventional therapies for hypoparathyroidism, using calcium, active vitamin D, and magnesium. We collected data on demographic features, disease- and treatment-related information, and results of routine laboratory tests, treatment adherence, and presence of complications. Beck Depression Inventory, Beck Anxiety Inventory, and Short Form-36 quality of life assessments were administered.Among the 300 patients studied, 60.7% were adherent to their treatment, and 34.1% had complications. Anxiety and depression scores were significantly higher in non-adherent versus treatment-adherent patients (p0.001 and p=0.001, respectively). Most of the domains of quality-of-life scores were also significantly lower in non-adherent patients. Both anxiety and depression scores showed significant, negative correlations with serum calcium and magnesium concentrations (Nearly 40% of the patients were non-adherent to conventional treatment for hypoparathyroidism, and such patients had higher anxiety and depression scores and poorer quality of life scores. Conventional treatment might not be sufficient to meet the needs of patients with hypoparathyroidism. In addition to seeking new therapeutic options, factors influencing quality of life should also be investigated and strategies to improve treatment adherence should be developed.This study aimed to evaluate the current situation of hypoparathyroid patients and to investigate the relationship between treatment adherence and quality of life.Prospective, multicentre study.Adult patients presenting with the diagnosis of hypoparathyroidism to 20 different endocrinology clinics were included. They were receiving conventional therapies for hypoparathyroidism, using calcium, active vitamin D, and magnesium. We collected data on demographic features, disease- and treatment-related information, and results of routine laboratory tests, treatment adherence, and presence of complications. Beck Depression Inventory, Beck Anxiety Inventory, and Short Form-36 quality of life assessments were administered.Among the 300 patients studied, 60.7% were adherent to their treatment, and 34.1% had complications. Anxiety and depression scores were significantly higher in non-adherent versus treatment-adherent patients (p0.001 and p=0.001, respectively). Most of the domains of quality-of-life scores were also significantly lower in non-adherent patients. Both anxiety and depression scores showed significant, negative correlations with serum calcium and magnesium concentrations (Nearly 40% of the patients were non-adherent to conventional treatment for hypoparathyroidism, and such patients had higher anxiety and depression scores and poorer quality of life scores. Conventional treatment might not be sufficient to meet the needs of patients with hypoparathyroidism. In addition to seeking new therapeutic options, factors influencing quality of life should also be investigated and strategies to improve treatment adherence should be developed. |
| Databáze: | OpenAIRE |
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