Safety evaluation of α-galacto-oligosaccharides for use in infant formulas investigated in neonatal piglets
| Autor: | Yu-Ting Zhou, Fanny Morel-Despeisse, Eric Chappuis, Claire L. Kruger, Bjorn A Thorsrud |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030109 nutrition & dietetics Sucrose Hematology Feed consumption Prebiotic medicine.medical_treatment Physiology 04 agricultural and veterinary sciences 040401 food science 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology chemistry Infant formula lcsh:RA1190-1270 Internal medicine Neonatal piglet medicine Histopathology Adverse effect lcsh:Toxicology. Poisons |
| Zdroj: | Toxicology Research and Application, Vol 1 (2017) |
| ISSN: | 2397-8473 |
| Popis: | Galacto-oligosaccharide (GOS), comprising galactoses with a glucose or sucrose, is a family of nondigestible oligosaccharides. The present study evaluates the safety of an α-GOS product (P-GOS® P) in a neonatal piglet model for 3 weeks. Three days after birth, neonatal piglets were divided into control and treated groups and provided with swine milk replacers in the absence and presence of 8 mg/mL—of the α-GOS product, respectively. An increase in the weight of the large intestines in treated males was noted, which is a common finding in studies of animals fed nondigestible oligosaccharides. There were no α-GOS product-related adverse effects in the piglets in terms of clinical signs, body weights, feed consumption, clinical chemistry, hematology, organ weights, or histopathology. The study demonstrated that formula supplemented with 8 mg/mL of P-GOS P is safe and well tolerated in neonatal piglets and supports the safe use of P-GOS P in infant formulas. |
| Databáze: | OpenAIRE |
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