Placing the Plasmodium falciparum epigenome on the map
| Autor: | Hendrik G. Stunnenberg, Richárd Bártfai, Wieteke A. M. Hoeijmakers |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Epigenomics
Genetics 0303 health sciences biology Extramural Plasmodium falciparum 030231 tropical medicine Epigenome biology.organism_classification 3. Good health Chromatin 03 medical and health sciences 0302 clinical medicine Infectious Diseases Evolutionary biology Humans Parasitology Epigenetics Malaria Falciparum Genome Protozoan Molecular Biology 030304 developmental biology |
| Zdroj: | Trends in Parasitology, 28, 11, pp. 486-495 Trends in Parasitology; Vol 28 Trends in Parasitology, 28, 486-495 |
| ISSN: | 1471-4922 |
| Popis: | It is becoming increasingly evident that epigenetic mechanisms that act on and regulate chromatin structure play a key role in the development, adaptation, and survival of the malaria parasite within its human host. The study of epigenetics in Plasmodium falciparum started to flourish in recent years due to improvement of genomic technologies. Here we summarize the knowledge gained from genome-wide localization profiling of different epigenetic features, and discuss hypotheses emerging from the analysis of these 'descriptive' epigenetic maps. Furthermore, we highlight key questions to be answered, and provide a glimpse of developments required to gain true mechanistic understanding and to lift this maturing field to the next level. |
| Databáze: | OpenAIRE |
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