Short survival of phosphatidylserine-exposing red blood cells in murine sickle cell anemia
| Autor: | Renee K. Emerson, Narla Mohandas, Kitty de Jong, James Butler, Jacob Bastacky, Frans A. Kuypers |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Hemolytic anemia Erythrocytes Recombinant Fusion Proteins Hemoglobin Sickle Immunology Mice Transgenic Spleen Anemia Sickle Cell Phosphatidylserines Biology Biochemistry Membrane Lipids Mice Reticulocyte medicine Animals Humans Biotinylation Erythropoiesis Red Cell Erythrocyte Membrane beta-Thalassemia Erythrocyte Aging Cell Biology Hematology Flow Cytometry medicine.disease Sickle cell anemia Globins Oxygen Red blood cell medicine.anatomical_structure Models Animal Cancer research Female Bone marrow |
| Zdroj: | Blood. 98:1577-1584 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v98.5.1577 |
| Popis: | Several transgenic murine models for sickle cell anemia have been developed that closely reproduce the biochemical and physiological disorders in the human disease. A comprehensive characterization is described of hematologic parameters of mature red blood cells, reticulocytes, and red cell precursors in the bone marrow and spleen of a murine sickle cell model in which erythroid cells expressed exclusively human α, γ, and βS globin. Red cell survival was dramatically decreased in these anemic animals, partially compensated by considerable enhancement in erythropoietic activity. As in humans, these murine sickle cells contain a subpopulation of phosphatidylserine-exposing cells that may play a role in their premature removal. Continuous in vivo generation of this phosphatidylserine-exposing subset may have a significant impact on the pathophysiology of sickle cell disease. |
| Databáze: | OpenAIRE |
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