Prognostic impact of tumor growth velocity in head and neck squamous cell carcinoma treated by radiotherapy: A pilot study
| Autor: | Gilles Delahaut, François Janot, Stéphane Temam, Sébastien Van der Vorst, Yungan Tao, Jérôme Ambroise |
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| Přispěvatelé: | UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CTMA - Centre de technologies moléculaires appliquées (plate-forme technologique), UCL - (MGD) Service d'oto-rhino-laryngologie |
| Rok vydání: | 2019 |
| Předmět: |
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medicine.medical_specialty medicine.medical_treatment Urology Pilot Projects Kaplan-Meier Estimate Disease-Free Survival 03 medical and health sciences 0302 clinical medicine medicine Humans Doubling time Tumor growth 030212 general & internal medicine Prospective cohort study Lymph node Pathological Neoplasm Staging Progression Squamous Cell Carcinoma of Head and Neck business.industry Oropharynx carcinomas Prognosis medicine.disease Head and neck squamous-cell carcinoma Tumor Burden Radiation therapy Oropharyngeal Neoplasms medicine.anatomical_structure Otorhinolaryngology Tumor progression 030220 oncology & carcinogenesis Disease Progression Female Tomography X-Ray Computed business Head |
| Zdroj: | Head & neck, Vol. 41, no. 9, p. 3041-3048 (2019) |
| ISSN: | 1097-0347 1043-3074 |
| DOI: | 10.1002/hed.25789 |
| Popis: | Background When a patient is seen with a newly diagnosed oropharyngeal squamous cell carcinoma, it remains unclear to the treating physicians how fast the tumor growth rate is. Methods From patients with oropharynx squamous cell carcinoma treated by radiotherapy, the investigators selected comparable diagnostic CT-scan (DiCT) and radiotherapy planning CT-scan (RtCT). Tumor and pathological lymph node volumes were measured in order to calculate tumor progression. Results From the selection of 19 patients, the mean absolute tumor progression rate was 0.23 ± 0.2 cm3 /d and mean relative progression rate was 1.84 ± 1.64%/d. Mean tumor doubling time is 286 days (range 7-1282 days), demonstrating a wide range of tumor growth pattern. Significant tumor progression (>20%) between DiCT and RtCT was shown in 73% of patients, and 53% of the patients were seen a tumor progression of >50% within a mean waiting time of 42.1 days. Kaplan-Meier curves showed a non-significative link between fast progression tumors (>1%/d) and higher risk of recurrence (HR: 2.2; P = .23). Conclusions Tumor progression can be assessed based on DiCT and RtCT. Treatment delay should be avoided at all cost. Different growth patterns were evidenced. For the fast-growing tumors subgroup, pejorative clinical outcomes were suggested. Prospective studies are needed to confirm a link between fast-growing tumors and higher risk for recurrence. |
| Databáze: | OpenAIRE |
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