Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: a pilot study
| Autor: | Kwanjit Danwilai, Bung-orn Sripanidkulchai, Suphat Subongkot, Jitprapa Konmun |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant ginger extract medicine.medical_treatment Ginger Extract antioxidant activity Placebo Gastroenterology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine emetogenic potential adjuvant chemotherapy Original Research chemistry.chemical_classification Chemotherapy business.industry Glutathione peroxidase Glutathione Malondialdehyde 030104 developmental biology Oncology chemistry Cancer Management and Research 030220 oncology & carcinogenesis Physical therapy business |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| Popis: | Kwanjit Danwilai,1,2 Jitprapa Konmun,2,3 Bung-orn Sripanidkulchai,4 Suphat Subongkot,2,4,5 1Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 2The College of Pharmacotherapy of Thailand, Nonthaburi, 3Department of Pharmacy, Ramathibodi Hospital, Mahidol University, Bangkok, 4Center for Research and Development of Herbal Health Products, 5Clinical Pharmacy Division, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand Purpose: The aim of this study was to examine the antioxidant activity of ginger extract oral supplement in newly diagnosed cancer patients receiving adjuvant chemotherapy compared to placebo.Patients and methods: Newly diagnosed cancer patients receiving moderate-to-high emetogenic potential adjuvant chemotherapy were randomized to receive either a ginger extract (standardized 6-gingerol 20mg/day) or a placebo 3days prior to chemotherapy, which they continued daily. Oxidant/antioxidant parameters, including the activities of superoxide dismutase (SOD) and catalase (CAT) and levels of glutathione peroxidase (GPx), total glutathione (GSH/GSSG), lipid peroxidation products detected as malondialdehyde (MDA) and NO2-/NO3-, were measured at baseline and at days 1, 22, 43 and 64 after undergoing chemotherapy. Two-sided statistical analysis, with P |
| Databáze: | OpenAIRE |
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