Effect of sufentanil on bispectral index in the elderly
| Autor: | Martin R. Tramèr, Nadia Elia, Christopher Lysakowski, Christoph Czarnetzki, T. de Valence, Lionel Dumont |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Sufentanil Sedation Unconsciousness Placebo 03 medical and health sciences 0302 clinical medicine Consciousness Monitors Double-Blind Method 030202 anesthesiology medicine Humans 030212 general & internal medicine Propofol Aged Aged 80 and over Sex Characteristics business.industry Confidence interval Anesthesiology and Pain Medicine Anesthesia Bispectral index Anesthesia Intravenous Female Anaesthesia induction medicine.symptom business Anesthetics Intravenous medicine.drug |
| Zdroj: | Anaesthesia. 73(2) |
| ISSN: | 1365-2044 |
| Popis: | We examined the impact of adding sufentanil during anaesthesia induction with propofol on bispectral index values in elderly patients (≥ 65 years). Patients were randomly assigned to receive a target-controlled sufentanil infusion (effect-site concentration of 0.3 ng.ml-1 ) or matching placebo, followed by a target-controlled propofol induction (initial effect-site concentration of 0.5 μg.ml-1 ; step-wise increase of 0.5 μg.ml-1 ) until loss of consciousness defined as an Observer's Assessment of Alertness/Sedation score < 2. Seventy-one patients (sufentanil 35, placebo 36) completed the study. Mean (SD) age was 72.3 (5.8) years; 41% were women. At loss of consciousness, mean (SD) bispectral index value was 75.0 (8.6) with sufentanil and 70.0 (8.0) with placebo; mean difference -5.0 (95% confidence interval -8.9 to -1.1), p = 0.013. Post-hoc analyses suggest that the difference was significant in men only (mean difference -7.3 (-11.8 to -2.6), p = 0.003). Sufentanil co-induction with propofol results in higher bispectral index values at loss of consciousness in elderly patients. |
| Databáze: | OpenAIRE |
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