Improving rehabilitation after critical illness through outpatient physiotherapy classes and essential amino acid supplement: A randomized controlled trial
| Autor: | Jane Eddleston, E. Coughlan, Richard D. Griffiths, D. McWilliams, Christina Jones, S. Dowling, Amanda J. McCairn |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Critical Care Critical Illness Glutamine medicine.medical_treatment Walking Anxiety Critical Care and Intensive Care Medicine law.invention Double-Blind Method Ambulatory care Randomized controlled trial Quality of life law Intensive care Ambulatory Care medicine Humans Physical Therapy Modalities Depression (differential diagnoses) Analysis of Variance Rehabilitation Depression business.industry Middle Aged Intensive care unit Exercise Therapy Intensive Care Units Dietary Supplements Quality of Life Physical therapy Female Amino Acids Essential medicine.symptom business |
| Zdroj: | Journal of Critical Care. 30:901-907 |
| ISSN: | 0883-9441 |
| DOI: | 10.1016/j.jcrc.2015.05.002 |
| Popis: | Patients recovering from critical illness may be left with significant muscle mass loss. This study aimed to evaluate whether a 6-week program of enhanced physiotherapy and structured exercise (PEPSE) and an essential amino acid supplement drink (glutamine and essential amino acid mixture [GEAA]) improves physical and psychological recovery.Intensive care patients aged 45 years or older, with a combined intensive care unit stay/pre-intensive care unit stay of 5 days or more were recruited to a randomized controlled trial examining the effect of PEPSE and GEAA on recovery. The 2 factors were tested in a 2 × 2 factorial design: (1) GEAA drink twice daily for 3 months and (2) 6-week PEPSE in first 3 months. Primary efficacy outcome was an improvement in the 6-minute walking test at 3 months.A total of 93 patients were randomized to the study. Patients receiving the PEPSE and GEA had the biggest gains in distance walked in 6-minute walking test (P.0001). There were also significant reductions in rates of anxiety in study groups control supplement/PEPSE (P = .047) and GEAA supplement/PEPSE (P = .036) and for GEAA supplement/PEPSE in depression (P = .0009).Enhanced rehabilitation combined with GEAA supplement may enhance physical recovery and reduce anxiety and depression. |
| Databáze: | OpenAIRE |
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