Epidemiology of UK neonatal infections:the neonIN infection surveillance network
| Autor: | Benjamin, Cailes, Christina, Kortsalioudaki, Jim, Buttery, Santosh, Pattnayak, Anne, Greenough, Jean, Matthes, Alison, Bedford Russell, Nigel, Kennea, Paul T, Heath, Prakash, Satodia |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics medicine.drug_class Antibiotics Sepsis 03 medical and health sciences 0302 clinical medicine Intensive Care Units Neonatal 030225 pediatrics Intensive care Epidemiology medicine Humans Infection control 030212 general & internal medicine Neonatology Retrospective Studies business.industry Incidence Incidence (epidemiology) Infant Newborn Obstetrics and Gynecology General Medicine medicine.disease United Kingdom Anti-Bacterial Agents Neonatal infection Pediatrics Perinatology and Child Health Female Neonatal Sepsis business |
| Zdroj: | Cailes, B, Kortsalioudaki, C, Buttery, J, Pattnayak, A, Greenough, A, Matthes, J, Bedford-Russell, A & Kennea, N & Heath, P 2017, ' Epidemiology of UK neonatal infections : the neonIN infection surveillance network ', Archive Dis Child . https://doi.org/10.1136/archdischild-2017-313203 |
| DOI: | 10.1136/archdischild-2017-313203 |
| Popis: | ObjectiveTo describe the epidemiology of neonatal infection over the past decade in UK neonatal units.DesignRetrospective analysis of prospectively collected infection surveillance network data from 2005 to 2014.Setting30 neonatal units in the UK.PatientsNewborns on participating neonatal units who had a positive blood, cerebrospinal fluid or urine culture and were treated with at least 5 days of appropriate antibiotics.Results2171 episodes of neonatal infection in 1922 infants were recorded. The incidence of infection was 6.1/1000 live births and 48.8/1000 neonatal admissions (2.9 and 23.5 respectively if coagulase-negative staphylococci (CoNS) cultures excluded). The incidence of infection showed a statistically significant reduction over time with reductions in the rates of both early-onset sepsis (EOS) and late-onset sepsis (LOS).The majority of episodes (76%) represented LOS (diagnosed > 48 hours after birth), and infection was more common in premature (Escherichia coli (18%) for EOS, while E. coli (15%), Staphylococcus aureus (14%) and CoNS were prominent causes of LOS.ConclusionsThis paper describes the epidemiology of neonatal infection in the UK over the past decade. These data enable benchmarking of practice and inform areas of future research and guideline development. The results support the hypothesis that the introduction of infection prevention care bundles and antibiotic stewardship programmes in the UK has reduced the burden of LOS. |
| Databáze: | OpenAIRE |
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