Post-streptococcal glomerulonephritis in Sydney: A 16-year retrospective review
| Autor: | Andrew R. Rosenberg, Christopher C Blyth, P. W. Robertson |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Native Hawaiian or Other Pacific Islander Adolescent Streptococcus pyogenes medicine.medical_treatment Population Skin infection chemistry.chemical_compound Glomerulonephritis Streptococcal Infections Internal medicine Epidemiology medicine Humans Child education Dialysis Hematuria Retrospective Studies Creatinine education.field_of_study business.industry Retrospective cohort study medicine.disease Pharyngitis Surgery chemistry Child Preschool Pediatrics Perinatology and Child Health Female New South Wales medicine.symptom business |
| Zdroj: | Journal of Paediatrics and Child Health. 43:446-450 |
| ISSN: | 1440-1754 1034-4810 |
| DOI: | 10.1111/j.1440-1754.2007.01109.x |
| Popis: | Aim: Post-streptococcal glomerulonephritis (PSGN) is a frequent cause of acute nephritis in children. Numerous studies have described PSGN in high-risk populations yet few data describing PSGN in a low-incidence population exist. This study aimed to describe the epidemiology, clinical manifestations, diagnosis, complications and outcomes of PSGN in an urban Australian population. Methods: A 16-year retrospective review of case notes and laboratory data was conducted at a tertiary Sydney paediatric hospital. Results: Thirty-seven children were treated for PSGN with a mean age of 8.1 years (range 2.6–14.1 years). Twenty-eight subjects (75.7%) had a history of a recent upper respiratory tract or skin infection. Hypertension and/or oedema was present in 29 subjects (78.4%). Streptococcal pharyngitis was identified as the likely source in 17 subjects (45.9%). Skin infections occurred less frequently. Antibodies against streptolysin O, streptokinase or deoxyribonuclease B were elevated when a single titre was measured in 35 subjects (94.6%). Thirty subjects (81.1%) developed renal impairment (median peak creatinine, 95 µmol/L, range 39–880 µmol/L). No correlation was demonstrated between peak creatinine, age, ethnicity, streptococcal titres and serum complement levels. The mean length of admission was 8.2 days. Seven subjects (18.9%) had a complicated course with three subjects requiring dialysis. Only one subject has ongoing renal dysfunction. Conclusion: Significant differences are seen in a low-incidence urban Australian population with PSGN when compared with endemic or epidemic disease in high-risk populations. The higher rates of complications that were seen compared with previously studied populations need further clarification. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text