An electrochemical sensor for quantitative analysis of Rhesus D antibodies in blood
| Autor: | Giovanni De Micheli, Sandro Carrara, Francesca Criscuolo, Irene Taurino, Tugba Kilic |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
blood typing Life quality 02 engineering and technology 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Medicine Electrochemical biosensor Pregnancy biology Hemolytic disease of the fetus and newborn business.industry Obstetrics electrochemical sensors 021001 nanoscience & nanotechnology medicine.disease Rhesus d Rh disease 3. Good health Electrochemical gas sensor Blood group antibodies electrochemical impedance spectroscopy biology.protein Antibody 0210 nano-technology business Quantitative analysis (chemistry) HDFN |
| Zdroj: | IWASI 2017 7th IEEE International Workshop on Advances in Sensors and Interfaces (IWASI) |
| DOI: | 10.1109/iwasi.2017.7974261 |
| Popis: | The Hemolytic Disease of the Fetus and Newborn (HDFN), if untreated, can have severe consequences on baby’s health, eventually causing death. Prevention and diagnosis of pregnancies at risk of HDFN consists in quantitative analysis in hospital every 2-4 weeks of blood group antibodies in maternal serum. The most important antibodies to be monitored are anti- Rhesus D (or anti-RhD) ones. Nowadays several portable systems for different healthcare applications have been developed towards decentralization of diagnosis thanks to the enormous advances in electrochemical biosensing. Home-monitoring of pregnancies at risk of HDFN could significantly improve patients’ life quality. Here we demonstrate for the first time label-free quantitative detection of anti-RhD antibodies by means of electrochemical impedance spectroscopy (EIS), suitable for integration within a complete portable device. The specificity of the sensor was also proved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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