Increased serum retinol-binding protein-4 levels in pregnant women with and without gestational diabetes mellitus
| Autor: | Qun Yan, Chen Xu, Jie Hong, Meng Dai, W. Gu, Man-yin Xu, Qiaorui Liu, Guang Ning, Zhen-ni Chi, Chun-fang Shen, Xiaoying Li, Yu Zhang, Yuxia Su, Wei Qing Wang, Yi Zhang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Body Mass Index Young Adult Endocrinology Insulin resistance Pregnancy Internal medicine Diabetes mellitus Internal Medicine medicine Homeostasis Humans Triglycerides Glucose tolerance test Retinol binding protein 4 medicine.diagnostic_test biology business.industry nutritional and metabolic diseases General Medicine Glucose Tolerance Test medicine.disease Gestational diabetes Diabetes Gestational Cross-Sectional Studies Postprandial Pregnancy Trimester Second biology.protein Gestation Female Insulin Resistance business Retinol-Binding Proteins Plasma Biomarkers |
| Zdroj: | Diabetes & Metabolism. 36:470-475 |
| ISSN: | 1262-3636 |
| DOI: | 10.1016/j.diabet.2010.06.006 |
| Popis: | Retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans, while pregnancy is normally characterized by progressive insulin resistance. Gestational diabetes (GDM) occurs when pancreatic beta-cell function is unable to compensate for insulin resistance. This study aimed to determine whether or not serum RBP4 levels are elevated in pregnancy, and to explore the relationship between RBP4 levels and insulin resistance during pregnancy.Serum RBP4 was measured at median gestational week 26 in 121 pregnant women, including 63 with GDM (GDM group) and 58 normal, glucose-tolerant pregnant women (P-NGT group), as well as 65 non-pregnant normal, glucose-tolerant women (NP-NGT group). Multiple stepwise regression analysis was used to explore the independent factors of RBP4.Serum RBP4 levels in the P-NGT and GDM groups were significantly higher than in the NP-NGT group (34.50±9.80 mg/L and 41.64±12.21 mg/L vs 30.64±9.46 mg/L, respectively; P0.05) after adjusting for age, body mass index (BMI) and blood pressure. Furthermore, RBP4 levels were much higher in the GDM vs P-NGT group. Spearman's correlation analysis showed that serum RBP4 levels were positively correlated with triglycerides (TG), fasting plasma glucose, postprandial 2h plasma glucose and HOMA-IR in pregnancy. Of these, TG and HOMA-IR (r(2)=0.312) were independent factors of serum RBP4.Serum RBP4 levels are significantly increased in pregnancy, independent of age and BMI, and are also considerably higher in pregnant women with GDM than in those with normal glucose tolerance. In addition, serum RBP4 levels appear to be a valuable marker of insulin resistance and dysfunctional lipid metabolism in pregnancy. |
| Databáze: | OpenAIRE |
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