Clinical markers and some trace elements in patients with type-2 diabetic nephropathy : Impact of insulin resistance
| Autor: | Sadoun Abbas Alsalimi, Nadhum Abdulnabi Awad, Adnan J. M. Al-Fartosy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Renal function General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Insulin resistance Internal medicine Diabetes mellitus medicine Humans Diabetic Nephropathies Creatinine biology business.industry Insulin nutritional and metabolic diseases General Medicine medicine.disease Trace Elements Cross-Sectional Studies Endocrinology Fructosamine Diabetes Mellitus Type 2 Cystatin C chemistry biology.protein Microalbuminuria Insulin Resistance business Biomarkers |
| Zdroj: | The Journal of Medical Investigation. 68:76-84 |
| ISSN: | 1349-6867 1343-1420 |
| Popis: | INTRODUCTION : Diabetic Nephropathy (DN) is the leading reason of all excess death-rate over type-2 diabetes mellitus (T2DM) patients with microalbuminuria, macroalbuminuria or end-stage renal disease. This work was aimed to estimate insulin resistance (IR) effect on some markers and trace elements (Selenium, Zinc, Magnesium) levels for early predicting of DN in T2DM patients. METHODS : We conducted a cross-sectional clinical study. Blood and urine samples were collected from 63 subjects with T2DM and 33 healthy controls to assess glucose, insulin, IR, urea, creatinine, glomerular filtration rate (GFR), creatinine clearance (CrCl), homocysteine (Hcy), fructosamine (FA), cystatin C (CysC), albumin (Alb), neutrophil gelatinase-associated lipocalin (NGAL), 8-hydroxy-2`-deoxyguanosine (8-OHdG) and trace elements levels. Data were collected using a questionnaire that was filled out by specialized doctors. RESULTS : Compared with controls, the results revealed that T2DM patients with or without DN had significant increases in glucose, insulin, IR, urea, creatinine, Hcy, FA, CysC, Alb, NGAL and 8-OHdG and significant decreases in GFR, CrCl and trace elements levels. Body mass index (BMI) had no changes. CONCLUSION : Uncontrolled T2DM was associated with BMI, IR and physical activity in which elevated Hcy, FA, CysC, Alb, NGAL and 8-OHdG levels and decreased trace elements levels may be used as early clinical markers of DN. J. Med. Invest. 68 : 76-84, February, 2021. |
| Databáze: | OpenAIRE |
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