Measurement of bicarbonate output from the intact human oesophagus
| Autor: | W. D. W. Rees, C. M. Brown, C. F. Snowdon, B. Slee, L. N. Sandle |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Saliva Adolescent Bicarbonate Gastroenterology pCO2 chemistry.chemical_compound Esophagus Pepsin Internal medicine medicine Humans Peristalsis Gastric Juice Mucous Membrane biology Chemistry digestive oral and skin physiology Biopsy Needle Hydrogen-Ion Concentration digestive system diseases Bicarbonates medicine.anatomical_structure biology.protein Gastroesophageal Reflux Gastric acid Female Perfusion Research Article |
| Zdroj: | Gut. 34(7) |
| ISSN: | 0017-5749 |
| Popis: | Injury of the oesophageal mucosa can result from exposure to refluxed gastric acid and pepsin. Competence of the lower oesophageal sphincter and peristaltic activity serve to reduce contract time between luminal acid and oesophageal mucosa, but intraluminal neutralisation of residual acid by bicarbonate may also be important in preventing oesophageal mucosal injury. Whereas swallowed saliva contains bicarbonate, recent experiments have also demonstrated alkali secretion from the mammalian oesophagus. Bicarbonate secretion from the human oesophagus was therefore examined with an intubation technique and perfusion of the oesophagus with a non-absorbable marker. Saliva, gastric, and oesophageal aspirates were collected and bicarbonate concentrations determined by measurements of pH and pCO2 or by back titration. In 32 normal subjects (17 women, 15 men) median basal oesophageal bicarbonate secretion determined by a pH/pCO2 method was 416 (range 139-1050) mumol/hour/10 cm. In a subgroup of 15 experiments median oesophageal bicarbonate output was 489 (range 157-1033) mumol/hour/10 cm (pH/pCO2 method) compared with a median alkali output of 563 (range 135-799) mumol/hour/10 cm as determined by back titration. The difference was not significant. Salivary contamination of the oesophagus accounted for 25% of all bicarbonate measured within the oesophagus and refluxed gastric bicarbonate accounted for 2.5%. Bicarbonate secretion from the normal human oesophagus may, in combination with swallowed salivary bicarbonate, play a part in preventing oesophageal mucosal damage due to refluxed gastric acid and pepsin. |
| Databáze: | OpenAIRE |
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