Establishment of a cut-point value of serum TNF-α levels in the metabolic syndrome
| Autor: | Carmen M. Gurrola-Díaz, Sergio Sánchez-Enriquez, Edith Oregon-Romero, Pedro M. García-López, Pedro Garzón de la Mora, Blanca E. Bastidas-Ramírez, Mercedes González-Hita, José F. Muñoz-Valle |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Population Blood Pressure Enzyme-Linked Immunosorbent Assay Inflammation Type 2 diabetes Sensitivity and Specificity Insulin resistance Reference Values Internal medicine Humans Immunology and Allergy Medicine education Mexico Aged Metabolic Syndrome education.field_of_study Chi-Square Distribution Anthropometry Tumor Necrosis Factor-alpha business.industry Biochemistry (medical) Public Health Environmental and Occupational Health Original Articles Hematology Middle Aged medicine.disease Medical Laboratory Technology Endocrinology Cytokine ROC Curve Female Tumor necrosis factor alpha medicine.symptom Metabolic syndrome business Biomarkers Blood Chemical Analysis Cut-point |
| Zdroj: | Journal of Clinical Laboratory Analysis. 23:51-56 |
| ISSN: | 1098-2825 0887-8013 |
| Popis: | Cardiovascular diseases and type 2 diabetes are the major causes of mortality in Mexico. Metabolic syndrome (MS) is a cluster of factors that increase the risk to develop such diseases. Previous studies have shown that MS is associated with high tumor necrosis factor (TNF‐α) levels. In fact, TNF‐α has been proposed to be a useful marker for clinical diagnosis of inflammation at an early stage. Therefore, we analyzed TNF‐α concentrations in Mexican individuals with or without MS and related these levels to the associated MS components. Clinical, anthropometric, and biochemical data were analyzed in 41 healthy and 39 MS individuals. Individuals were similarly grouped by age and gender.The serum TNF‐α levels measured bya highly sensitive enzyme‐linked immunosorbent assay (ELISA) kit were increased significantly in MS subjects compared with healthy individuals (P |
| Databáze: | OpenAIRE |
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