Breast conservative therapy in Pakistani women: Prognostic factors for locoregional recurrence and overall survival
| Autor: | Arif Jamshed, Amina Iqbal Khan, Abu Bakar Hafeez Bhatti, M. A. Shah |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Prognostic variable Multivariate analysis Adolescent Breast conservative therapy medicine.medical_treatment Breast Neoplasms Mastectomy Segmental survival lcsh:RC254-282 Young Adult Breast cancer Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging Pakistan Stage (cooking) Survival analysis Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Analysis Surgery Lymphatic Metastasis outcome Hormonal therapy Female Neoplasm Recurrence Local business Mastectomy Follow-Up Studies |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 11, Iss 2, Pp 300-304 (2015) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | Objectives: Breast conservative therapy (BCT) is an established method of treating early stage invasive breast cancer. Survival after BCT in Pakistani population has not been reported. This study was carried out to report locoregional control and overall survival (OS) after BCT for invasive breast cancer and analyze prognostic factors in Pakistani population. Materials and Methods: Patients who received BCT between 1997 and 2009 were included in the study. Patients' follow-up, demographics, prognostic variables and treatment modalities were assessed. Data were analyzed for locoregional and distant relapse and estimated 10-year locoregional recurrence free survival (LRRFS) and OS was calculated using Kaplan Meier curves. To determine the significance of prognostic variables, univariate and multivariate analysis was performed. Results: A total of 902 patients underwent BCT. Median age was 42 (17-82) years and the median follow-up was 51 (1.4-187) months. There were 484 (53.6) poorly differentiated and 194 (21.5) triple negative tumors. T3/T4 tumors were found in 128 (14.1) patients and 441 (44.8) patients had nodal involvement. Among adverse events, 58 (6.3) locoregional failures, 152 (16.8) distant failures and 155 (17.1) deaths were observed. Estimated 10 years LRRFS- was 88% while OS was 70%. On multivariate analysis, tumor size and nodal involvement were independent predictors of locoregional recurrence-free and OS. In addition, hormonal therapy significantly affected OS. Conclusion: BCT has acceptable long-term results in Pakistani women. Tumor size and nodal involvement are independent predictors of survival. |
| Databáze: | OpenAIRE |
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