Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design
| Autor: | Ana Paula Ramos, Wallance Moreira Pazin, Pietro Ciancaglini, Amando Siuiti Ito, Marcos A.E. Cruz, Sandra Y. Fukada, Mariana P. R. Soares |
|---|---|
| Přispěvatelé: | Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2019 |
| Předmět: |
Langmuir
Surface Properties 02 engineering and technology Morin 01 natural sciences Fluorescence chemistry.chemical_compound Surface modification Colloid and Surface Chemistry Adsorption Coordination Complexes 0103 physical sciences Monolayer Humans Flavonoid-metal complexes Particle Size Physical and Theoretical Chemistry Lipid bilayer Cells Cultured Langmuir monolayers Cell Proliferation TITÂNIO Flavonoids Titanium Osteoblasts Molecular Structure 010304 chemical physics Chemistry Optical Imaging Cell Differentiation Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology Membrane Chemical engineering Strontium Drug Design Wettability Thermodynamics 0210 nano-technology Biotechnology Octadecylphosphonic acid |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0927-7765 |
| Popis: | Made available in DSpace on 2019-10-04T12:15:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-09-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Flavonoid-metal complexes are widely studied because of their interesting luminescent behavior and biological activity. Despite the extensive exploration of flavonoid-metal coordination processes in solution, the formation of complexes using the flavonoid molecule inserted in a lipid membrane has been little investigated. This effect could provide important insight into the biological activity of flavonoids at lipid membranes and could represent an attractive strategy to design supramolecular structures. Here, we studied the complexation between Sr2+ and morin inserted in an octadecylphosphonic acid (OPA) Langmuir monolayer. This is a relevant system due to the synergism imposed by the association of the Sr2+ ability to control bone formation/resorption with the morin antioxidative effect. Morin incorporation into the OPA monolayers and further Sr2+ complexation were monitored by surface pressure isotherms. Electronic absorption spectroscopy and fluorescence techniques showed Srmorin complexation both in solution and at the air-liquid interface. Although morin complexation has been described to occur only at basic pH, the specific thermodynamic properties at the air-liquid interface drove metal complexation. LB films were deposited on Ti surfaces, and the resulting OPA/Sr-morin coatings exhibited high surface free energy and increase on its polar component. This optimized surface feature supported further serum protein adsorption and osteoblast growth and differentiation, indicating that these lipid-based coatings are promising for bioactive coating design. This study paves the way for the use of this lipid-based coating in the design of implants for faster osteointegration. Moreover, flavonoid-metal complexation at membranes could also help to shed light on the biological role played by flavonoids. Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, Sao Paulo, Brazil Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo, Brazil Univ Sao Paulo, Dept Fis, Fac Filosofia Ciencias & Letras Ribeirao Preto, Sao Paulo, Brazil Univ Estadual Paulista, Dept Fis, Fac Ciencias & Tecnol, Sao Paulo, Brazil Univ Estadual Paulista, Dept Fis, Fac Ciencias & Tecnol, Sao Paulo, Brazil FAPESP: 2015/08774-0 FAPESP: 2017/08892-9 FAPESP: 2016/21236-0 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect